Muhammad Miftahussurur and Chyntia Dewi Maharani Putri and Titong Sugihartono and Ari Fahrial Syam and Herry Purbayu and Diah Priyantini and Hartono Kahar and Yudith Annisa Ayu Rezkitha and Iswan Abbas Nusi and Poernomo Boedi Setiawan and Ummi Maimunah and Langgeng Agung Waskito and Ulfa Kholili and Budi Widodo and Amie Vidyani and Husin Thamrin and Gontar Alamsyah Siregar and Reny I'tishom and Tomohisa Uchida and Yoshio Yamaoka (2022) Urease Levels and Gastritis Stage in Dyspeptic Patients. Acta Medica Indonesiana, 54 (1). pp. 42-45. ISSN 1259326

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Abstract

Background: Dyspepsia is a frequent main symptom of inpatients and outpatients scenario in Indonesia. However, the number of endoscopy facilities are still low, thus the use of non-invasive method to detect gastritis is necessary. We measured the relationship between urease levels and the stage of gastritis in dyspeptic adult patients. Methods: A cross-sectional study included outpatient dyspepsia patient from November 2018 to February 2019. We examined 14C-Urea Breath Test (UBT) and determined the stage of gastritis based on the Updated Sydney System classification. Results: The urease level of acute and chronic gastritis positive patients were higher than negative patients (p = 0.001, r = 0.353; p <0.0001, r = 0.433, respectively). The AUC value of 14C-UBT to detect acute, chronic, and atrophic gastritis are 0.889, 0.632 and 0.544, respectively. The best cut-off points of 14C-UBT to predict acute gastritis was ≥26.50δ‰ with sensitivity and specificity being 88.89% and 63.95%, respectively. Whereas the best cut-off points for chronic gastritis was ≥34.50δ‰ with 82.89% sensitivity, 63.16% specificity. As for atrophic gastritis, it showed very low AUC value, hence it is not a sufficient test modality to predict atrophic gastritis cases. Conclusion: 14C-UBT is sufficient for predicting acute or chronic gastritis but not for atrophic gastritis.

Item Type:	Article
Subjects:	R Medicine > RC Internal medicine > RC31-1245 Internal medicine
Divisions:	01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:	Creators NIM Muhammad Miftahussurur NIDN0029097909 Chyntia Dewi Maharani Putri UNSPECIFIED Titong Sugihartono NIDN8836800016 Ari Fahrial Syam UNSPECIFIED Herry Purbayu NIDN8884800016 Diah Priyantini UNSPECIFIED Hartono Kahar NIDN8809020016 Yudith Annisa Ayu Rezkitha UNSPECIFIED Iswan Abbas Nusi NIDN0028025003 Poernomo Boedi Setiawan NIDN8886900016 Ummi Maimunah NIDN8896900016 Langgeng Agung Waskito UNSPECIFIED Ulfa Kholili NIDN0004047511 Budi Widodo NIDN8804800016 Amie Vidyani NIDN0028018002 Husin Thamrin NIDN8825800016 Gontar Alamsyah Siregar UNSPECIFIED Reny I'tishom NIDN0023107105 Tomohisa Uchida UNSPECIFIED Yoshio Yamaoka UNSPECIFIED
Depositing User:	Ika Rudianto
Date Deposited:	28 Apr 2023 13:21
Last Modified:	28 Apr 2023 13:21
URI:	http://repository.unair.ac.id/id/eprint/125570
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