Mochamad Zakki Fahmi*, .- and Abdul Haris, .- and Ahmadi Jaya Permana, .- and Denika Liyan Nor Wibowo, .- and Bambang Purwanto, .- and Yatim Lailun Nikmah, .- and Adi Idris, .- (2018) Bamboo leaf-based carbon dots for efficient tumor imaging and therapy. RSC Advances, 8 (67). pp. 38376-38383. ISSN 2046-2069

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Abstract

In this study, carbon dots synthesized from bamboo leaf cellulose were used simultaneously as a staining agent and for doxorubicin delivery to target cancer cells. Owing to their nontoxic properties, the production of carbon dots from bamboo leaves is a green approach involving optimized application of bamboo tree waste. For multifunctional applications, the carbon dots were modified with 4-carboxybenzylboronic acid and doxorubicin to improve target specificity and drug delivery to HeLa tumor cells. The resulting modified carbon dots were characterized using different analytical techniques, which showed that they were biocompatible, nontoxic, and highly stable over a wide range of pH values and at high ionic strengths. Furthermore, in vitro confocal microscopy studies demonstrated their blue fluorescence and cellular pathway for entering HeLa cells via folate receptor-mediated endocytosis. Cell viability data and flow cytometry results also confirmed the selective uptake of the carbon dots by HeLa cells, which significantly enhanced cell cytotoxicity.

Item Type:	Article
Subjects:	Q Science Q Science > Q Science (General) Q Science > QD Chemistry Q Science > QD Chemistry > QD450-801 Physical and theoretical chemistry
Divisions:	08. Fakultas Sains dan Teknologi > Kimia
Creators:	Creators NIM Mochamad Zakki Fahmi*, .- UNSPECIFIED Abdul Haris, .- UNSPECIFIED Ahmadi Jaya Permana, .- UNSPECIFIED Denika Liyan Nor Wibowo, .- UNSPECIFIED Bambang Purwanto, .- UNSPECIFIED Yatim Lailun Nikmah, .- UNSPECIFIED Adi Idris, .- UNSPECIFIED
Depositing User:	Mr Vega Andi Budiman
Date Deposited:	09 Jun 2023 03:03
Last Modified:	09 Jun 2023 03:03
URI:	http://repository.unair.ac.id/id/eprint/125910
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