Naproxen release behavior from graphene oxide/cellulose acetate composite nanofibers

Wulan Purnamasari, .- and Titah Aldila Budiastanti, .- and Aminatun, .- and Ulfa Rahmah, .- and Sri Sumarsih, .- and Jia-Yaw Changc, .- and Mochamad Zakki Fahmi*, .- (2022) Naproxen release behavior from graphene oxide/cellulose acetate composite nanofibers. RSC Advances, 12 (13). pp. 8019-8029. ISSN 2046-2069

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The present study investigated the effect of graphene oxide in cellulose acetate-based composite nanofibers on the transdermal delivery of naproxen. The composite nanofibers were successfully produced via the electrospinning process by directly mixing cellulose acetate, graphene oxide, and naproxen solution with varied compositions. The formation of the nanofibers was confirmed by electron microscopy and other characterization techniques to prove the existence of graphene oxide and naproxen itself. Surprisingly, graphene oxide encourages the production of nanofibers with smaller average diameter, higher conductivity, higher mechanical strength, and higher naproxen release from the cellulose acetate nanofibers. Once combined with naproxen, the composite nanofiber exhibited antibacterial activity with an inhibitory zone of 9.15 mm. The cytotoxicity evaluation also showed that the addition of naproxen increased the death of HeLa cells with a CC50 of up to 29.33 μg mL−1. The kinetic model of naproxen release follows the Korsmeyer–Peppas and Higuchi models with acceleration at neutral pH. These results are promising for further applications for wound healing purposes.

Item Type: Article
Subjects: Q Science
Q Science > QD Chemistry
Q Science > QD Chemistry > QD450-801 Physical and theoretical chemistry
Divisions: 08. Fakultas Sains dan Teknologi > Kimia
Wulan Purnamasari, .-UNSPECIFIED
Titah Aldila Budiastanti, .-UNSPECIFIED
Ulfa Rahmah, .-UNSPECIFIED
Sri Sumarsih, .-UNSPECIFIED
Jia-Yaw Changc, .-UNSPECIFIED
Mochamad Zakki Fahmi*, .-UNSPECIFIED
Depositing User: Mr Vega Andi Budiman
Date Deposited: 09 Jun 2023 04:54
Last Modified: 09 Jun 2023 04:54
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