Human serum albumin capsulated hydrophobic carbon nanodots as staining agent on HeLa tumor cell

Mochamad Zakki Fahmi*, .- and Denika Liyan Nor Wibowo, .- and Satya Candra Wibawa Sakti,, .- and Hwei Voon Lee, .- and Isnaeni, .- (2020) Human serum albumin capsulated hydrophobic carbon nanodots as staining agent on HeLa tumor cell. Materials Chemistry and Physics, 239 (1). pp. 1-9. ISSN 0254-0584

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The hydrophobic carbon nanodots (CDs) are promising nanoparticles to develop due to its uniformly size, good photoluminescence properties, and easy surface-modification. Highly photoluminescent hydrophobic CDs have been synthesized by carbonization of tartaric acid–l-tyrosine precursors. These hydrophobic CDs showed uniformly size distribution and exhibited strong–blue emission under UV irradiation. Further surface modification using human serum albumin (HSA) lead to the formation of hydrophilic CDs-HSA within low toxicity and good colloidal stability over varied pH and high ionic strengths. Various spectroscopies characterizations were done to analyze the morphological and chemical composition of both CDs and CDs-HSA. Further improvement analyses on cytotoxicity and confocal laser microscopy (CLSM) upon HeLa tumor cell suggested that the designed CDs-HSA was effective to be applied as staining agent against tumor cells.

Item Type: Article
Uncontrolled Keywords: Hydrophobic carbon nanodots, Human serum albumin, HeLa, Staining agent, Nanoparticle
Subjects: Q Science
Q Science > QD Chemistry
Q Science > QD Chemistry > QD450-801 Physical and theoretical chemistry
Divisions: 08. Fakultas Sains dan Teknologi > Kimia
Mochamad Zakki Fahmi*, .-UNSPECIFIED
Denika Liyan Nor Wibowo, .-UNSPECIFIED
Satya Candra Wibawa Sakti,, .-UNSPECIFIED
Hwei Voon Lee, .-UNSPECIFIED
Depositing User: Mr Vega Andi Budiman
Date Deposited: 09 Jun 2023 04:17
Last Modified: 09 Jun 2023 04:17
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