Kinetical release study of copper ferrite nanoparticle incorporated on PCL/collagen nanofiber for naproxen delivery

Tri Prasetyo Armedya, .- and Muhammad Fathan Dzikri, .- and Satya Candra Wibawa Sakti, .- and Abdulloh Abdulloh, .- and Yanuardi Raharjo, .- and Siti Wafiroh, .- and Purwati,, .- and Mochamad Zakki Fahmi*, .- (2019) Kinetical release study of copper ferrite nanoparticle incorporated on PCL/collagen nanofiber for naproxen delivery. Bionanoscience, 9 (2). pp. 274-284. ISSN 2191-1630 ; 2191-1649

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Nanofiber has become one of tissue engineering examples and has extensive application on medical field, particularly as a wound healing and wound dressing. In this research, nanofiber composite based on polycaprolactone and collagen was successfully obtained via electrospinning process and further developed as host of naproxen as anti-inflammatory agents. Addition of copper ferrite (CuFe2O4) nanoparticles on the nanocomposite becomes an advance part on this study to control of naproxen release. Several characterizations were furnished to prove the design composite nanofiber and its drug release analysis performed to find out the kinetic model and naproxen release mechanism from nanofibers. CuFe2O4 nanoparticles have potential to be used to control naproxen release in nanofiber that lead to decrease level of drug released, where mostly follow the Korsmeyer-Peppas model. The release of naproxen was certainly influenced by pH value, in which the drug was easier to release on base, instead of acid or neutral condition. Varied naproxen and nanoparticle compositions were prepared to reach optimum formulation of the release. This study provides fundamental data for the effect of magnetic nanoparticle on drug release process.

Item Type: Article
Uncontrolled Keywords: Nanofiber, Drug delivery system, Magnetic nanoparticle, Naproxen, Kinetic of drug release
Subjects: Q Science
Q Science > QD Chemistry
Q Science > QD Chemistry > QD450-801 Physical and theoretical chemistry
Divisions: 08. Fakultas Sains dan Teknologi > Kimia
Tri Prasetyo Armedya, .-UNSPECIFIED
Muhammad Fathan Dzikri, .-UNSPECIFIED
Satya Candra Wibawa Sakti, .-UNSPECIFIED
Abdulloh Abdulloh, .-UNSPECIFIED
Yanuardi Raharjo, .-UNSPECIFIED
Siti Wafiroh, .-UNSPECIFIED
Mochamad Zakki Fahmi*, .-UNSPECIFIED
Depositing User: Mr Vega Andi Budiman
Date Deposited: 10 Jun 2023 05:48
Last Modified: 10 Jun 2023 05:48
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