Dual Function of Silver Nanoparticles as Matrix Extracell Removal and Antimicrobial Agent in Polymycrobial Biofilms

Mei Shirli Yasinta, .- and Hera Lisna Ginawati, .- and Nira Ambar Arum, .- and Harini Nur Hikmah, .- and Sri Sumarsih, .- and Mochamad Zakki Fahmi*, .- and Afaf Baktir, .- (2021) Dual Function of Silver Nanoparticles as Matrix Extracell Removal and Antimicrobial Agent in Polymycrobial Biofilms. Indonesian Journal of Chemistry, 21 (2). pp. 286-295. ISSN 1411-9420 ; 2460-1578

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Official URL: https://jurnal.ugm.ac.id/ijc/article/view/52355/30...


Candida albicansoften form polymicrobial biofilms along with pathogenic microbes. Silver nanoparticles (AgNPs) were well known to have strong antimicrobial activity. However, their effect on polymicrobialbiofilms and the mechanism has never been reported. This study aimed to synthesize AgNPs and study their effects on polymicrobial biofilm represented by C. albicans–E. colibiofilm. Polymicrobial biofilms, formed by clinical isolates of C. albicansand E.coli, were developed from the standardized suspensions of each strain by culturing flat-bottom 96-well microtiter plates for 48 h then treated with AgNPs. Cell viability was assessed using the tetrazolium salt reduction assay; the extent of biofilm formation was measured by crystal violet staining. AgNPs reduced the polymicrobial biofilm in two ways: by degrading the extracellular matrix and killing both C. albicansand E. coli. The results showed AgNPs area potential new approach for developing potent anti-biofilms

Item Type: Article
Uncontrolled Keywords: silver nanoparticle; polymicrobial biofilm; C. albicans; E. coli; anti-biofilm
Subjects: Q Science
Q Science > Q Science (General)
Q Science > QD Chemistry
Q Science > QD Chemistry > QD450-801 Physical and theoretical chemistry
Divisions: 08. Fakultas Sains dan Teknologi > Kimia
Mei Shirli Yasinta, .-UNSPECIFIED
Hera Lisna Ginawati, .-UNSPECIFIED
Nira Ambar Arum, .-UNSPECIFIED
Harini Nur Hikmah, .-UNSPECIFIED
Sri Sumarsih, .-UNSPECIFIED
Mochamad Zakki Fahmi*, .-UNSPECIFIED
Afaf Baktir, .-UNSPECIFIED
Depositing User: Mr Vega Andi Budiman
Date Deposited: 12 Jun 2023 00:19
Last Modified: 12 Jun 2023 00:19
URI: http://repository.unair.ac.id/id/eprint/125947
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