Incorporation of imprinted-zeolite to polyethersulfone/cellulose acetate membrane for creatinine removal in hemodialysis treatment

Yanuardi Raharjo, .- and Mochamad Zakki Fahmi, .- and Siti Wafiroh, .- and Alfa Akustia Widati, .- and Eviomitta Rizki Amanda, .- and Ahmad Fauzi Ismail, .- and Mohd Hafiz Dzarfan Othman, .- and Djoko Santoso, .- (2019) Incorporation of imprinted-zeolite to polyethersulfone/cellulose acetate membrane for creatinine removal in hemodialysis treatment. Jurnal Teknologi (Sciences and Engineering), 81 (3). pp. 137-144. ISSN 0127-9696 ; 2180-3722

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Polyethersulfon (PES) membrane has been widely used in the biomedical field especially in hemodialysis application. Many modifications of membranes have been applied into hemodialysis such as diffusion, adsorption, and mixed-matrix membrane. The main problem of those membranes is less selectivity to attract the uremic toxins. In this study, we report the modification of PES mixed with cellulose acetate (PES/CA) membrane as mixed-matrix membrane (MMM) using imprinted-zeolite (PES/CA/IZC) in order to increase the selectivity for targeted analyte. The hollow fibre membranes (HFM) were fabricated by dry-wet spinning technique. The successful zeolite A synthesised and was characterised by x-ray diffraction (XRD). The mixed-matrix membranes were characterised in terms of morphology using scanning electron microscopy (SEM), water contact angle (WCA), pure water flux (PWF), clearance of creatinine (CC), and BSA adsorption. In accordance with the results of characterisation, the synthesis of zeolite A, and imprinted-zeolite creatinine was successfully fabricated. The SEM results showed that the PES/CA/IZC membrane has uniform pores and fingerlike structure. The same result was obtained for PES/CA membrane, but not for PES/CA/ZA membrane. The WCA of the PES/CA; PES/CA/ZA; and PES/CA/IZC were 85.63; 84.98; and 77.53 (o), respectively. While the PWF were 22.84; 27.57, and 40.52 (Lm-2h-1), respectively. The addition of imprinted-zeolite into the membrane improved creatinine removal up to 74.99%. It showed that PES/CA/IZC has succeeded in increasing the selectivity of membranes to attract the creatinine as target analyte. Compared to the PES/CA, the creatinine clearance of membranes improved and increased up to 5.2%. For protein rejection, the PES/CA/IZC rejected 79.05% of bovine serum albumin (BSA). Based on these results, it can be concluded that PES/CA/IZC can be considered as hemodialysis membranes.

Item Type: Article
Uncontrolled Keywords: Hemodialysis membrane, polyethersulfon, cellulose acetate, imprinted-zeolite, creatinine
Subjects: Q Science
Q Science > QD Chemistry
Q Science > QD Chemistry > QD450-801 Physical and theoretical chemistry
Divisions: 08. Fakultas Sains dan Teknologi > Kimia
Yanuardi Raharjo, .-UNSPECIFIED
Mochamad Zakki Fahmi, .-UNSPECIFIED
Siti Wafiroh, .-UNSPECIFIED
Alfa Akustia Widati, .-UNSPECIFIED
Eviomitta Rizki Amanda, .-UNSPECIFIED
Ahmad Fauzi Ismail, .-UNSPECIFIED
Mohd Hafiz Dzarfan Othman, .-UNSPECIFIED
Djoko Santoso, .-UNSPECIFIED
Depositing User: Mr Vega Andi Budiman
Date Deposited: 12 Jun 2023 00:18
Last Modified: 12 Jun 2023 00:18
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