Hery Suwito, .- and Helda Dwi Hardiyanti, .- and Kautsar Ul Haq, .- and Alfinda Novi Kristanti, .- and Miratul Khasanah, .- (2018) (E)-3-[3-(4-Morpholinophenyl)acryloyl]-2H-chromen2-one. Molbank, 2018 (4). pp. 1-5. ISSN 1422-8599

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Abstract

A new compound (E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one, a coumarin based chalcone derivative, has been successfully synthesized employing a molecular hybridization method through the reaction between 3-acetylcoumarin and 4-morpholinobenzaldehyde using a Claisen–Schmidt reaction using pTSA as a catalyst. The structure of the title compound was established using spectroscopic data FTIR, HRESI-MS, 1H- and 13C-NMR. The anticancer activity against breast cancer cells line T47D and cervix cancer cells line HeLa was determined using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.

Item Type:	Article
Uncontrolled Keywords:	molecular hybridization; coumarin-chalcone; anticancer
Subjects:	Q Science Q Science > Q Science (General) Q Science > QD Chemistry Q Science > QD Chemistry > QD71-142 Analytical chemistry
Divisions:	08. Fakultas Sains dan Teknologi > Kimia
Creators:	Creators NIM Hery Suwito, .- UNSPECIFIED Helda Dwi Hardiyanti, .- UNSPECIFIED Kautsar Ul Haq, .- UNSPECIFIED Alfinda Novi Kristanti, .- UNSPECIFIED Miratul Khasanah, .- UNSPECIFIED
Depositing User:	Mr Vega Andi Budiman
Date Deposited:	09 May 2023 00:09
Last Modified:	03 Jun 2023 07:07
URI:	http://repository.unair.ac.id/id/eprint/125992
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