Correlation between C-MYC and BAX expression with various Ann Arbor stages in B-cell large cell type of Non-Hodgkin lymphoma

Ariadna Anggi Pasang, - and Alphania Rahniayu, - and Nila Kurniasari, - and I Ketut Sudiana, - and Willy Sandhika, - and Anny Setijo Rahaju, - and Dyah Fauziah, - and Siprianus Ugroseno Yudho Bintoro, - (2023) Correlation between C-MYC and BAX expression with various Ann Arbor stages in B-cell large cell type of Non-Hodgkin lymphoma. Research Journal of Pharmacy and Technology, 16 (2). pp. 597-602. ISSN 0974-3618

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Official URL: https://www.rjptonline.org/AbstractView.aspx?PID=2...

Abstract

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is one of the B-cell large cell types of non-Hodgkin lymphoma (NHL) that has poor prognosis with highly variable clinical course. Various prognostic factors have been proposed to predict this, but the results were variable. C-MYC is a proto-oncogen that can cause overexpression leading to the increased of tumor cells proliferation. BAX is a main proapoptotic member of the BCL-2 family proteins that regulates apoptotic function. The study aimed to analyze correlation of c-MYC and BAX protein with various Ann Arbor stages in B-cell large cell type of NHL. This cross-sectional study was performed on 39 formalin fixed paraffin-embedded tissue of patients diagnosed as B-cell large cell type of NHL during January 2017 - December 2019 in Anatomical Pathology Laboratory at Dr. Soetomo General Hospital, Surabaya. To assess the expression of c-MYC and BAX, the immunohistochemistry examination was performed. Immunoexpression of C-MYC and BAX were evaluated according to the number of positive tumor cells divided by the total number of tumor cells and calculated in percentage. There was no difference in C-MYC (p = 0.877) and BAX (p = 0.093) expression with various Ann Arbor stages in B-cell large cell type of NHL. There was no correlation between c-MYC with BAX expression in various Ann Arbor stages in B-cell large cell type of NHL (rs = 0.206, p = 0.209). This indicated that C-MYC and BAX expression alone could not to be used as parameters to predict the outcome of the B-cell large cell type of NHL via Ann Arbor stages.

Item Type: Article
Subjects: R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions: 01. Fakultas Kedokteran > Patologi Anatomi
Creators:
CreatorsNIM
Ariadna Anggi Pasang, -UNSPECIFIED
Alphania Rahniayu, -NIDN0007028106
Nila Kurniasari, -UNSPECIFIED
I Ketut Sudiana, -NIDN0005075507
Willy Sandhika, -UNSPECIFIED
Anny Setijo Rahaju, -NIDN0020097009
Dyah Fauziah, -NIDN0005127309
Siprianus Ugroseno Yudho Bintoro, -NIDN8807700016
Depositing User: arys fk
Date Deposited: 03 May 2023 02:32
Last Modified: 29 May 2024 00:03
URI: http://repository.unair.ac.id/id/eprint/126020
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