Hanifa Erlin Damayanti, - and Aditiawarman, - (2015) 25(OH)D Inadequacy Has Different Pathway with VEGF in Increases the Risk of Severe Preeclampsia. Majalah Obstetri & Ginekologi, 23 (2). pp. 42-48. ISSN 25981013

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Abstract

Objectives: To identify in vivo correlation between 25(OH)D and VEGF in severe preeclampsia. Materials and Methods: A case control, cross sectional study of 36 pregnant women which consist of 18 patients with preeclampsia and 18 patients as control with gestational age-matched. We perform 25(OH)D serum examination by chemiluminescent immunoassay (CLIA) and VEGF serum examination by sandwich ELISA to all patients. Results: All patients are in 25(OH)D insufficiency and deficiency state. Both maternal 25(OH)D and VEGF levels were inversely associated with the risk of preeclampsia (both P<0.05). There is no correlation between 25(OH)D serum level and VEGF serum level (P=0,629). Conclusion: Maternal vitamin D deficiency is associated with increased preeclampsia risk. However, our data do not support the hypothesis that the association between vitamin D deficiency and preeclampsia is mediated by impaired level of VEGF.

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