Indah Lestari, - and Bagus Setyoboedi, - and Martono Tri Utomo, Martono A protective status of HbsAg and Anti-HBs in vaccinated newborns from hepatitis B positived mothers: a meta analysis. I. International Journal of Research Publications, 82 (1). pp. 46-57. ISSN 2708-3578

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Abstract

Abstract Background: Mother-to-child transmission of hepatitis B virus makes a significant contribution to chronic hepatitis B virus infection. One strategy to prevent hepatitis B transmission from mother to child is by administering hepatitis B immunoglobulin (HBIg) and hepatitis B vaccination. Methods: This meta-analysis used secondary data from articles taken from 2000 to 2020 through the PubMed database, Google Scholar. There were 5 articles for antiHbs and 4 articles for HBsAg that matched the inclusion and exclusion criteria. Analysis using the Revman Review Manager 5.4. Results: The comparison of the proportion and confidence interval on HBsAg and anti-HBs status after hepatitis B vaccination in infants of HBsAg positive mothers showed that anti-HBs results with a combined effect magnitude of 0.89 (95% CI 0.83; 0.94), p < 0.05 while HBsAg status with a combined effect of 0.09 (95% CI 0.03; 0.015), p < 0.05. Conclusion: The successful proportion of hepatitis B vaccination with HbIg is 89% and HbsAg positive status in infants is 9%.

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