Profil Kadar Interleukin-31 Serum pada Pasien Dermatitis Atopik Repository

Profil Kadar Interleukin-31 Serum pada Pasien Dermatitis Atopik

Dewi Kusumawati, - and Cita Rosita Prakoeswa, - and Rahmadewi, - (2017) Profil Kadar Interleukin-31 Serum pada Pasien Dermatitis Atopik. Berkala Ilmu Kesehatan Kulit dan Kelamin, 29 (2). pp. 142-150. ISSN 2549-4082

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Official URL: https://e-journal.unair.ac.id/BIKK/article/view/55...

Abstract

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by pruritic skin lesion. Pathogenesis of AD is not fully understood, but recent studies demonstrate the role of interleukin-31 (IL-31). This cytokine is considered to be a potential mediator inducing pruritus in AD. Several studies reported a direct correlation between serum IL-31 level and severity of AD, probably due to the ability of this cytokine to increase the inflammatory response through the initiation of the expression of proinflammatory cytokines and chemokines. Purpose: To evaluate the serum level of IL-31 in AD patients. Methods: Thirty-four AD patients who defined according to the criteria of United Kingdom (UK) Working Party were included in this descriptive observational cross-sectional study. Samples were taken from peripheral venous blood and IL-31 serum levels were measured using ELISA. Results: Mean IL-31 serum level was 99.43±72.91 pg/mL, with the lowest level of 6.84 pg/mL and the highest level of 281.25 pg/mL. Conclusion: IL-31 seems to have a role in atopic dermatitis but further investigation is required.

Item Type:

Article

Uncontrolled Keywords:

dermatitis atopik, interleukin-31 serum, ELISA

Subjects:

R Medicine > R Medicine (General)
R Medicine > RL Dermatology

Divisions:

01. Fakultas Kedokteran > Ilmu Kesehatan Kulit dan Kelamin (Spesialis)

Creators: