Retha, - and Sawitri, - and Rahmadewi, - and Afif Nurul Hidayati, - and Muhammad Yulianto Listiawan, - and Evy Ervianti, - and Linda Astari, - and Cita Rosita Sigit Prakoeswa, - (2020) Combination of Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E for Photoaging. Berkala Ilmu Kesehatan Kulit dan Kelamin, 32 (1). pp. 1-6. ISSN 2549-4082

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Abstract

Background: It is hypothesized that combination of amniotic membrane stem cell metabolite product (AMSC-MP) and vitamin E after fractional CO2 laser as laser assisted drug delivery (LADD) provides better long-term effects on clinical improvement of photoaging. This is promising as an option for photoaging therapy in the future. Purpose: The study aimed to evaluate long-term effects of improving the degree of wrinkles, polarized black spots, ultraviolet (UV) black spots, pores, and skin tones in subjects who have received a topical mixture of AMSC-MP with vitamin E and CO2 fractional laser as LADD. Methods: Thirty adult women with photoaging who had been treated with topical AMSC-MP mixed therapy with vitamin E and CO2 fractional laser three times, were then given maintenance therapy, tretinoin cream 0.025% and sunscreen SPF 30. Observation of improvement of wrinkles, polarized black spots, UV black spots, pores, and skin tones were performed computer-stimulated photographs, Janus-II Facial Skin Scope System, three times every month for three months after the last treatment. Results: The evaluation of wrinkles, polarized black spots, UV dark spots, pores and skin tones from the assessment for three months after being receiving treatment of a topical mixture of AMSC-MP with vitamin E and CO2 fractional laser as LADD on photoaging obtained p>0.05. Conclusion: There was a long-term effect of the topical mixture of AMSC-MP with vitamin C and CO2 fractional laser on photoaging, and there was no side effect observed.

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