Prihartini Widiyanti, - and ADITA WARDANI RAHMANIA, 081411731010 and Siswanto, - (2023) Synthesis and characterization of cryogel apple pectin-chitosan as physical barrier intraperitoneal antiadhesion postsurgical. -. ISSN -

	Text (Turnitin) Turnitin Synthesis and Characterization of Cryogel.pdf Download (1MB)
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Abstract

Abstract. Peritoneal Adhesion achieve high rates of general surgery and gynecological surgery.Adhesion can cause intestinal obstruction, slow healing process after surgery, abdominal pain and even death Cryogel aple pectin-chitosan is a new study that uses pectin from apples, chitosan and reacts with methods cryotopic gelation. This study will prove the effect of variations in chitosan concentration (0.6%, 0.7%, 0.8% and 0.9%) and identify the optimal concentration of chitosan through Fourier Transform Infrared (FTIR) test, tensile test and degradation test. The FTIR test results show that there is a vibration of protonated amine group (NH3+) around the wave number of 1600 cm-1 and there is polyelectrolyte complex bonding. The optimal composition of intraperitoneal antiadhesi membrane is at 0.9% chitosan concentration with Ultimate Tensile Strength of 1.241 MPa, and the degradation rate of 87.9% on the 7th day. Based on the results of tensile test and degradation test, the higher concentration of chitosan, the lower Ultimate Tensile Strength and the faster degradation rate. Optimal composition is found in cryogel sample with 90% chitosan concentration.

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