Nengcy Erlina Tasik Rerung, - and Andi Cahyadi, - and Nur Rochmah, - and Maria Christina Shanty Larasati, - and Mia Ratwita Andarsini, - and Muhammad Faizi, - (2020) Hyperglicemia in childhood acute lymphoblastic leukemia during induction chemotherapy. Indian Journal of Forensic Medicine & Toxicology, 15 (1). pp. 1373-1378. ISSN 0973-9130

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Abstract

Background: Hyperglycemia is a recognized side effect of the corticosteroids and asparaginase given during induction chemotherapy for pediatric acute lymphoblastic leukemia (ALL). The ALL is the malignant tumor with the highest incidence in the childhood. The aim of this study is to investigate the impact of hyperglycemia during induction chemoteraphy in childhood ALL. Methods: This prospective study was done in Dr. Soetomo hospital from January to April 2018. The subject was newly diagnosed as ALL under the age of 18 years, treated with Indonesian childhood ALL 2013 protocol (Standard Risk (SR) group and High Risk (HR) group). Hyperglycemia was defined as at least two separate random plasma glucose levels > 200 mg/dL, which was evaluated before and during induction chemotherapy. Statistical analysis using Paired T-test for parametric and Wilcoxon Test for nonparametric. Results: Thirty-three children were enrolled, 18/33 boys with mean age 5.8 (SD 3.78) years, compromised as ALL-L1 30/33. They were treated with ALL-HR 19/33 and ALL-SR 14/33. In overall groups, the mean random blood glucose level significantly increased from 108 (SD 21.3) mg/dL to 147 (SD 48.1) mg/dL, (mean difference 38.67 mg/dL; 95% CI 18.08 to 59.26 mg/dL, P=0.008). In SR group, there was a significant increased of mean random blood glucose level from 102 (SD 13.5) mg/dL to 133 (SD 37.3) mg/dL, (mean difference 31.8 mg/dL; 95% CI 8.78 to 54.8 mg/dL; P=0.01). In HR group, the mean random blood glucose level increased from 113 (SD 51.9) mg/dL to 165 (SD 25.4) mg/dL, (mean difference 51.9 mg/dL; 95% CI 18.6 to 85.2 mg/dL, P=0.004).

Item Type:	Article
Uncontrolled Keywords:	Blood glucose level is significantly increase during induction chemotherapy in both SR and HR
Subjects:	R Medicine > R Medicine (General) R Medicine > RJ Pediatrics
Divisions:	01. Fakultas Kedokteran > Ilmu Kesehatan Anak (Sub Spesialis)
Creators:	Creators NIM Nengcy Erlina Tasik Rerung, - NIM011428116311 Andi Cahyadi, - UNSPECIFIED Nur Rochmah, - NIDN0029047909 Maria Christina Shanty Larasati, - UNSPECIFIED Mia Ratwita Andarsini, - NIDN0024017302 Muhammad Faizi, - NIDN8890900016
Depositing User:	Mrs Elok Dian Nuraeni
Date Deposited:	29 May 2023 23:01
Last Modified:	29 May 2023 23:01
URI:	http://repository.unair.ac.id/id/eprint/126825
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• Hyperglicemia in childhood acute lymphoblastic leukemia during induction chemotherapy. (deposited 29 May 2023 23:01) [Currently Displayed]
  • Hyperglicemia in childhood acute lymphoblastic leukemia during induction chemotherapy. (deposited 25 Jun 2023 11:18)

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