Effectiveness of selenium supplementation in children with autoimmune thyroiditis: A Systematic Review and Meta-Analysis

Yuni Hisbiyah, - and Anang Endaryanto, - and Bagus Setyoboedi, - and Nur Rochmah, - and Muhammad Faizi, - and Citrawati Dyah Kencono Wungu, - and Qurrota Ayuni Novia Putri, - (2022) Effectiveness of selenium supplementation in children with autoimmune thyroiditis: A Systematic Review and Meta-Analysis. International Journal of Health Sciences, 6 (89). pp. 1395-1410. ISSN 2550-696X

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Official URL: https://sciencescholar.us/journal/index.php/ijhs/a...

Abstract

Deficiencies of Selenium (Se) is correlated with the risk and onset of autoimmune thyroid disease (AITD). The aim of this study was to determine the association between Se supplementation and AITD. Methods: Electronic data searches of 4 databases were performed. We assessed the included studies using PRISMA for protocol assurance. Five studies met our inclusion criteria and were analyzed. The predictor covariate in the present study was Se administration. The outcome measures were levels of thyroid peroxidase antibodies (TPO-Ab), thyroglobulin antibody (Tg-Ab), free thyroxine (fT4), and thyroid volume. Results: Of the five studies that met the inclusion criteria, one randomized controlled trial (RCT) was included in the qualitative review, whereas four quasi-experimental studies were included in the meta-analysis. The results showed that Se supplementation significantly reduced TPO-Ab levels (MD 90.85; 95% CI 61.71–120.00; p<0.00001) and fT4 levels (MD 1.52; 95% CI, 0.55–2.50; p=0.002), while the RCT showed that Se supplementation significantly reduced Tg-Ab levels. Conclusions: Se supplementation significantly reduces TPO-Ab and fT4 levels in children and adolescents with AITD. The limited number of studies and population sizes emergence of further studies especially RCTS are needed to make a better meta-analysis.

Item Type: Article
Uncontrolled Keywords: autoimmune thyroid disease, Selenium, Thyroid antibody
Subjects: R Medicine > R Medicine (General)
R Medicine > RJ Pediatrics
Divisions: 01. Fakultas Kedokteran > Ilmu Kesehatan Anak (Sub Spesialis)
Creators:
CreatorsNIM
Yuni Hisbiyah, -NIM011927017307
Anang Endaryanto, -NIDN8867700016
Bagus Setyoboedi, -NIDN8889700016
Nur Rochmah, -NIDN0029047909
Muhammad Faizi, -NIDN8890900016
Citrawati Dyah Kencono Wungu, -NIDN0022128803
Qurrota Ayuni Novia Putri, -NIM011411131047
Depositing User: Mrs Elok Dian Nuraeni
Date Deposited: 29 May 2023 22:57
Last Modified: 29 May 2023 22:57
URI: http://repository.unair.ac.id/id/eprint/126832
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