Muhammad Faris, Muhammad and Budi Utomo, Budi and Asra Al Fauzi, Asra and I. Ketut Sudiana, I. Ketut and Sri Maliawan, Sri and Yoes Prijatna Dahlan, Yoes and Oski Illiandri, Oski and Moh Hasan Machfoed, - and Abdul Hafid Bajamal, Abdul ACTH4-10PRO8-GLY9-PRO10 improves Neutrophil profile in spinal cord injury of rat models. Journal of Advanced Pharmacy Education and Research, 11 (2). ISSN 2249-3379

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Abstract

Abstract Acute spinal cord injury (SCI) is a health burden that affects daily function. Based on its prevalence, SCI becomes a major problem in the country. Inflammation is one of SCI property that stays as the main target for management in the last decade. ACTH4-10PRO8-GLY9-PRO1 (Met-Glu-His-Phe-Pro-Gly-Pro) has been known for its anti-inflammatory properties but remains unclear for SCI models. This experimental study was done on the SCI model of the Sprague-Dawley rat. Neutrophil was taken as an inflammatory marker from the spinal cord of the rat model on 3 and 6 hours of observation following injury. Statistical analysis was done using ANOVA comparison test with significance cut off of p < 0.05, CI 95%. Six samples from each control and treatment group (normal saline 3 and 6 hours; ACTH4-10PRO8-GLY9-PRO10 3 and 6 hours) were observed for immunoreacted values of neutrophil staining to assess inflammatory reactions in spinal cord injury models. Statistical analysis continued with the Kruskal-Wallis test and found significant differences (p < 0.001) between groups. Post-hoc tests were carried out using the Steel method. The most significant difference in Neutrophil levels was found in the ACTH4-10PRO8-GLY9-PRO10 6 hours group against normal saline 6 hours.

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