The Role Of Vitamin d Deficiency Towards Cognitive Deficit Of Schizophrenia

Azimatul Karimah, - and Kristanti Sulistyo Rahayu, - and Aryati, - (2020) The Role Of Vitamin d Deficiency Towards Cognitive Deficit Of Schizophrenia. Eurasian Journal Of Bioscience, 14 (-). pp. 1833-1837. ISSN 13079867

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Abstract

Background: Vitamin D receptor (VDR) discovery in the brain tissue demonstrates clearly that vitamin D has a significant role in the development of the brain. This study aimed to analyze the correlation between serum vitamin D levels and cognitive deficits in schizophrenic patients. Methods: This was an observational analytic study with cross-sectional design. Serum vitamin D levels were measured using VIDAS® 25 OH Vitamin D Total (VITD). Cognitive deficits were measured using Indonesian version of the Schizophrenia Cognition Rating Scale (ScoRSvI). Results: This study recruited 54 patients from outpatient and inpatient unit of psychiatric. Most of subjects were male as many as 25 (65.8%). Mean age of subjects was 34.84 years. Mean duration of illness was 10.58±7.4 years. There were 17 (45%) subjects experienced serum vitamin D deficiency, and 22 (58%) study subjects had cognitive deficits on the global impression of ScoRSvI assessment by rater. There was a significant negative correlation (p <0.001) between serum vitamin D levels and SCoRSvI values from the impression of global observations, ScoRSvI patients, and ScoRSvI informants. Conclusion: The lower serum vitamin D levels, the higher score of cognitive deficits from SCoRSvI. The higher SCoRSvI score shows the more severe cognitive deficit for patients with schizophrenia.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: 01. Fakultas Kedokteran > Ilmu Kedokteran Jiwa
Creators:
CreatorsNIM
Azimatul Karimah, -NIDN8880900016
Kristanti Sulistyo Rahayu, -NIM011228186305
Aryati, -NIDN0015086304
Depositing User: Unnamed user with email indah.fatma@staf.unair.ac.id
Date Deposited: 09 Jun 2023 02:40
Last Modified: 09 Jun 2023 02:57
URI: http://repository.unair.ac.id/id/eprint/127067
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