Impact of COVID-19 Lockdown on the Metabolic Control Parameters in Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis

Ifan Ali Wafa, - and Nando Reza Pratama, - and Nurizzah Farahiyah Sofia, - and Elsha Stephanie Anastasia, - and TIFFANY KONSTANTIN, NIM011611133102 and MAHARANI AYUPUTERI WIJAYA, NIM011611133103 and M. RIFQI WIYONO, NIM011611133129 and Lilik Djuari, - and Hermina Novida, - (2022) Impact of COVID-19 Lockdown on the Metabolic Control Parameters in Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis. Diabetes & Metabolism Journal, 46 (2). pp. 260-272. ISSN 2233-6079

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Official URL: https://e-dmj.org/upload/pdf/dmj-2021-0125.pdf

Abstract

Background: Abrupt implementation of lockdowns during the coronavirus disease 2019 (COVID-19) pandemic affected the management of diabetes mellitus in patients worldwide. Limited access to health facilities and lifestyle changes potentially affected metabolic parameters in patients at risk. We conducted a meta-analysis to determine any differences in the control of metabolic parameters in patients with diabetes, before and during lockdown. Methods: We performed searches of five databases. Meta-analyses were carried out using random- or fixed-effect approaches to glycaemic control parameters as the primary outcome: glycosylated hemoglobin (HbA1c), random blood glucose (RBG), fasting blood glucose (FBG), time-in-range (TIR), time-above-range (TAR), time-below-range (TBR). Mean difference (MD), confidence interval (CI), and P Value were calculated. Lipid Profile was a secondary outcome and is presented as a descriptive analysis. Results: Twenty-one Studies enrolling a total of 3,992 patients With type 1 or Type 2 diabetes Mellitus (T1DM Or T2DM) Were included in the study. Patients With T1DM Showed a significant improvement of TIR and TAR (MD=3.52% [95% CI, 0.29 to 6.74], I 2 =76%, P=0.03; MD=–3.36% [95% CI, –6.48 to –0.25], I 2 =75%, P=0.03), while FBG among patients with T2DM significantly worsened (MD=3.47 mg/dL [95% CI, 1.22 to 5.73], I 2 =0%, P<0.01). No significant difference was found in HbA1c, RBG, and TBR. Use of continuous glucose monitoring in T1DM facilitated good glycaemic control. Significant deterioration of lipid parameters During lockdown, particularly triglyceride, was observed. Conclusion: Implementation Of lockdowns during the COVID-19 Pandemic did not worsen glycaemic control in patients with diabetes. Other Metabolic parameters improved during lockdown, though lipid parameters, particularly triglyceride, worsened.

Item Type: Article
Uncontrolled Keywords: COVID-19; Diabetes mellitus; Meta-analysis; Systematic review; Triglycerides
Subjects: R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions: 01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:
CreatorsNIM
Ifan Ali Wafa, -UNSPECIFIED
Nando Reza Pratama, -NIM011611133101
Nurizzah Farahiyah Sofia, -NIM011611133148
Elsha Stephanie Anastasia, -NIM011611133104
TIFFANY KONSTANTIN, NIM011611133102NIM011611133102
MAHARANI AYUPUTERI WIJAYA, NIM011611133103NIM011611133103
M. RIFQI WIYONO, NIM011611133129NIM011611133129
Lilik Djuari, -NIDN0030036508
Hermina Novida, -NIDN0012117705
Depositing User: Miftachul Miftachul Mujayanah Mifta
Date Deposited: 12 Jun 2023 11:31
Last Modified: 12 Jun 2023 11:31
URI: http://repository.unair.ac.id/id/eprint/127232
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