Hermina Novida, - and sri murtiwi, - and Askandar Tjokroprawiro, - and Agung Pranoto, - and A. Sutjahjo, - and S. Adi, - and Sony Wibisono, - (2014) Are There Any Correlations Between Ratio LDL-C/HDL-C and Lipoprotein(A) With Insulin Resistance in Type 2 Diabetes Patients With Abdominal Obesity? In: Diabetes Research and Clinical Practice, November 2014, Surabaya.

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Abstract

Background: Obesity and diabetes have recently become so prevalent across the world that it is replacing undernourishment and infectious disease. Dyslipidemis is another risk factor for metabolic syndrome and on the other hand, dyslipidemia is also associated with insulin resistance. Increased low density lipoprotein cholesterol (LDL-C) are atherogenic, whereas increased of high density lipoprotein cholesterol (HDL-C) is considered canliontective. The ratio of LDL-C to HDE C is currently advocated to estimate the risk of coronary artery disease. Insulin resistance and Lipoprotein(a) (pa)) also have been proposed as independent risk factor of cardiovascular disease. The relationship between type 2 diabetes, an insulin resistant condition with Ip(a) concentration and also ratio lipoprotein remains controversial. The aim of this study is to analyze the correlation of ratio LDL-C/HDL-C and Lp(a) with insulin resistance in type 2 diabetes patients with abdominal obesity. Method. We analyzed 78 patients with type 2 diabetes and abdominal obesity coasting of 54 male and 24 female patients using cross sectional observational design. Blood pressure, brady weight, height and waist circumference (WC) were messed and body mass index (BMI) were calculated. Abdominal obosity was defined by WC >80 cm in women and >90 cm in men. We measured fasting plasma glucose (FPG) and post prandial glucose (PPG), HbA1c,total cholesterol (TC), LDL-C, HDL-C, ratio LDL-C/HDL-C, triglyceride (TG), Lp(a) and basal insulin. Inviter resistance can be assessed by using homesotasis tals model assessment (HOMA) from fasting serum insulin concentrataion HOMA of insulin resistance (HOMA-IR) is a simple, inexpensive and non-laborious technique. Data was statistically analyzed using logistic regression test. Result: The mean age of the patiens in this study was 57.47+11.04 years old, with duration diabetes was 8.38+1 .64 years. The average BMI in this sady was 29.52+3.73 kgm2. The overall meas of FPG in these patients was 181.19+72.52mg/dl, while PPG was 263.63+115.87 mg/dL and HbA1c was 9.66+8.03%. Lipid profile of the patients showed the average level of TC was 199+50.99 mg/dL. LDL-C 1was 124.55+36.49 mg/dL, HDLC 43.95+10.21 mg/DL, ratio LDL- C/HDL-C was 2.94+1.01 mg/dL. TG was 189.39+168.88 mg/dL, and Lp(a) was 20.10+3.96 mg/dL. The mean of fasting insulin level in this study was 24.55+5.85 uIU/mL, and HOMA-IR 428+2.26. stastical test showed that there was no significant conlation between ratio LDL- C/HDL-C and Lp(a) with HOMA-IR (r0.012; p 091 and r 0.126; p 0.271) Conclusion: Rasio LDL-CHDL-C and La) levels des corele sal inside resistance is type 2 diabetes patients with abdominal obesity.

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