Sri Sumarsih, .- and Muthia Dewi Pratiwi, .- and Indah Nur Ainni,, .- and Hardinata Rachmad Sinatriya,, .- and Soegeng Soegijanto,, .- and Teguh Hari Sucipto,, .- and Harsasi Setyawati*, .- (2020) The influence of metal on the performance of 2,4,5-triphenylimidazole as an inhibitor of dengue virus replication. Asia Pacific Journal of Molecular Biology and Biotechnology, 28 (3). pp. 113-121. ISSN 0128-7451

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Abstract

Dengue is a contagious disease caused by dengue virus and transmitted to humans by the bite of infected Aedes aegypti mosquito. Imidazole and its derivatives are proven have ability impairing dengue virus. One of potential imodazole’s derivatives is 2,4,5-triphenylimidazole (TPI). The presence of metal to the 2,4,5-triphenylimidazole (TPI) structure through a complex compound formation highly contributes to their ability as an inhibtor dengue virus replication. Iron, cobalt and zinc were used as an ion center in the complex compound. Complex Zn-TPI and Fe-TPI showed low cytotoxic effect at all the evaluated concentrations (viability > 50%). Complex Co-TPI showed reduction of DENV-3 growth, at the lowest concentration (6.25 µg/ml) exhibited the antiviral activity (DENV-3 reduction 43%). For Fe-TPI and ZnTPI, the reduction values of DENV-3 were 56% and 54.9% respectively.

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