T. H. Sucipto, .- and F. Martak, .- and H. Setyawati,, .- and N. Ertanti,, .- and I. K. Murwani, .- (2019) Synthesis and anti-cancer activity of copper (II) complex with 2, 4, 5-triphenyl-1H-imidazole ligand. Biochemical and Cellular Archives, 19 (2). pp. 4839-4843. ISSN 09725075, 09761772

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Abstract

The ligand 2,4,5-triphenyl-1H-imidazole (L) has been used to synthesize copper(II) complex, [Cu(L)2 (H2O)2].Cl2.The complex is well characterized from various spectral and physical meausrements. Complex synthesis resulted in obtaining a green, light crystalline solid. The maximum absorbance, at 529 nm, indicated bonding had occurred within the metal-ligand that is Cu-N in region 422.38 cm-1. Cytotoxicity was tested for in complex compounds made by the method of (3-(4,5-dimethylthiazol2-yl)-2,5-diphenyltetrazolium bromide) (MTT). The value of cytotoxicity activity (CC50) of complex compounds against T74D and HeLa cells was 8.78 µg/ml, 14.46 µg/ml, respectively, indicating promising anticancer activity. The complex enhanced growth inhibition; the cells exhibited better anticancer activities in both the T74D and HeLa cell lines. Despite potent in vitro activity, this complex compound exhibited a cytotoxicity against the normal Vero cells at an effective concentration.

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