The Effect of Topical Epigallocatechin-3-gallate (EGCG) on Collagen type-I, MMP-1 Expression and Dermal Collagen Count in Photoaging Prevention

Damayanti, Damayanti and Cita Rosita Sigit Prakoeswa, - and Djoko Agus Purwanto, - and Anang Endaryanto, - and Muhammad Yulianto Listiawan, - and Yohanes Widodo Wirohadidjojo, - and Soetjipto, - and Siswandono, - and Budi Utomo, - and Widjiati, - (2023) The Effect of Topical Epigallocatechin-3-gallate (EGCG) on Collagen type-I, MMP-1 Expression and Dermal Collagen Count in Photoaging Prevention. Chiang Mai University Journal of Natural Sciences, 22 (1). pp. 1-12. ISSN 1685-1994

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Official URL: https://cmuj.cmu.ac.th/nlsc/journal/article/974

Abstract

The increasing of life expectancy in world population, increases the risk of photoaging. Photoaging of the skin is a complex biologic process especially caused by ultraviolet irradiation. Photoaging becomes new concern issue, because of high public awareness of skin health and performance. Many agents had been tried to be an alternative prevention for photoaging, such as green tea. Epigallocatechin-3-gallate (EGCG) is the most abundant catechin in green tea, that showed its possibility to be an alternative agent in photoaging prevention. This study was aimed to evaluate the effect of topical EGCG in photoaging prevention by evaluating collagen type-1, MMP-1 expression and dermal collagen count in photoaging animal model. This was an animal in vivo study. Male Wistar rats aged 10-12 weeks were acclimated for 1 week and randomly divided into 6 groups: without intervention, ultraviolet irradiated group, ultraviolet irradiated group with topical EGCG (2.590, 590, 1090), and ultraviolet irradiated group with topical based cream (control group). The effect of topical EGCG in collagen type-1, MMP-1 expression and dermal collagen count were evaluated after 5 weeks of treatment. The mean of collagen type-I expression in group treated with topical EGCG were higher than control group, meanwhile the MMP-1 expression was lower than control group. Topical EGCG prevented the reduction of dermal collagen count significantiy (P «0.05). It showed that topical EGCG plays role in photoaging prevention.

Item Type: Article
Uncontrolled Keywords: Topical EGCG, Photoaging, Collagen type-I, MMP-1, Dermal collagen count, Life expectancy
Subjects: R Medicine
Divisions: 01. Fakultas Kedokteran > Ilmu Kesehatan Masyarakat
Creators:
CreatorsNIM
Damayanti, DamayantiUNSPECIFIED
Cita Rosita Sigit Prakoeswa, -NIDN8865610016
Djoko Agus Purwanto, -NIDN0008055906
Anang Endaryanto, -NIDN8867700016
Muhammad Yulianto Listiawan, -NIDN8806800016
Yohanes Widodo Wirohadidjojo, -UNSPECIFIED
Soetjipto, -NIDN0017025004
Siswandono, -NIDN0002105207
Budi Utomo, -NIDN0018055904
Widjiati, -NIDN0015046204
Depositing User: Miftachul Miftachul Mujayanah Mifta
Date Deposited: 08 Aug 2023 03:09
Last Modified: 08 Aug 2023 03:09
URI: http://repository.unair.ac.id/id/eprint/127969
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