Damayanti Tinduh, - and Cita Rosita Sigit Prakoeswa, - and Djoko Agus Purwanto, - and Anang Endaryanto, - and Muhammad Yulianto Listiawan, - and Yohanes Widodo Wirohadidjojo, - and Soetjipto, - and Siswandono, - and Budi Utomo, - (2023) Wistar Rat as Photoaging Mouse Model. Journal of Pakistan Association of Dermatologists, 33 (1). pp. 24-29. ISSN 1560-9014

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Abstract

Background The increasing of human life expectancy may cause aging problems, including photoaging. Photoaging raises new problems in community, because its influence in human selfesteem and guality of life. Studies about photoaging have been extensively performed to enhance the basic mechanism of photoaging. Mouse skin is usually used as cutancous aging model, because it is genetically similar to human skin. Methods This study was true experimental study, post test only-control group design that was aimed to evaluate the role of ultraviolet (UV) B imadiation to produce photoaging mouse model. Twenty-four Wistar rats were divided randomly allocation into 2 groups, namely non-UV irradiated group and UV irradiated group. Ultraviolet B irradiation were performed for 5 weeks until reaching the total dose 3100 ml/em'. Dermal collagen density and transepidermal water loss (TEWL) level were evaluated after the intervention. Results Dermal collagen density in non-UV irradiated group and UV irradiated group were 38.2122.6794 and 27.7320.7726. TEWL level in non-UV irradiated group and UV irradiated group were 7.5520.89 g/m'/h and 17.5323.94 g/m“/h. There was significant difference between the groups in dermal collagen density and TEWL level (p-0.05). Conclusion Wistar rat in UV irradiated group that were given total dose 3100 mJ/em? of UV B for 5 weeks has been proven to become photoaging mouse model.

Item Type:	Article
Uncontrolled Keywords:	Photoaging, mouse model, wistar rat, UV B, life expectancy
Subjects:	R Medicine
Divisions:	01. Fakultas Kedokteran > Ilmu Kesehatan Masyarakat
Creators:	Creators NIM Damayanti Tinduh, - NIDN8889900016 Cita Rosita Sigit Prakoeswa, - NIDN8865610016 Djoko Agus Purwanto, - NIDN0008055906 Anang Endaryanto, - NIDN8867700016 Muhammad Yulianto Listiawan, - NIDN8806800016 Yohanes Widodo Wirohadidjojo, - UNSPECIFIED Soetjipto, - NIDN0017025004 Siswandono, - NIDN0002105207 Budi Utomo, - NIDN0018055904
Depositing User:	Miftachul Miftachul Mujayanah Mifta
Date Deposited:	08 Aug 2023 05:20
Last Modified:	08 Aug 2023 05:20
URI:	http://repository.unair.ac.id/id/eprint/127975
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