Correlation of serum D-dimer level and the event microvessel cardiac thrombosis observed on core biopsy in post mortem COVID-19 Patients in Dr. Soetomo Hospital Surabaya, Indonesia

Achmad Lefi, Achmad and Lalu Galih Pratama Rinjani, - and Muhammad Yusuf Alsagaff, - and Raden Mohammad Budiarto, - and Priangga Adi Wiratama, - and Etty Hary Kusumastuti, - and Isnin Anang Marhana, - and Alfian Nur Rosyid, - and Dwi Wahyu, - and Bambang Pujo Semedi, - and Ricardo Adrian Nugraha, - and Ryan Ernast Intan, - and Muhammad Ramadhan, - and Ika Caesarina, - and Asiyah Nurul Fadila, - and Muhammad Surya Tiyantara, - and Gilang Muhammad Setyo Nugroho, - and Ummi Maimunah, - and Edi Suyanto, - and Adhitri Anggoro, - and I Komang Rusgi Yandi, - and Jilieanastasia Godrace Lilihata, - Correlation of serum D-dimer level and the event microvessel cardiac thrombosis observed on core biopsy in post mortem COVID-19 Patients in Dr. Soetomo Hospital Surabaya, Indonesia. Bali Medical Journal, 12 (2). pp. 2040-2045. ISSN ISSN:2089-1180E-ISSN:2302-2914

[img] Text (Artikel)
1. Correlation of serum D-dimer.pdf

Download (1MB)
[img] Text (Kualitas Karil & Kesesuaian Bidang Ilmu)
1.pdf

Download (792kB)
[img] Text (Turnitin)
1. Correlation of serum D-dimer.pdf

Download (2MB)
[img] Text (Bukti Korespondensi)
Berkas korespondensi dr Achmad Lefi.pdf

Download (1MB)
Official URL: https://www.balimedicaljournal.org/index.php/bmj/a...

Abstract

Abstract Link of Video Abstract: https://youtu.be/ivpwfj9PxWQ Background: Microvascular coronary thrombosis is an emerging risk factor that worsens the prognosis of COVID-19 patients. This study aims to show for the first time a descriptive of histopathologic findings from post-mortem COVID-19 patients and to analyze whether D-Dimer serum level, a marker of hyper-coagulopathy, correlates with coronary microvascular thrombosis from the cardiac core biopsy. Method: This was an observational analytic study with a retrospective cohort design from July-December 2020. Cardiac core biopsy was taken from patients who died while treated at the isolation ICU at Dr. Soetomo due to severe COVID-19. The samples were taken in 1-hour post-mortem and then analyzed histopathologically with Hematoxylin-eosin staining under a light microscope to evaluate the presence of coronary microvascular thrombosis and other pathological findings from the cardiac biopsy. Clinical information and D-Dimer levels from medical records and analyzed for coronary microvascular thrombosis using Man-Whitney and C-statistic analysis using SPSS 22 software. Result: There were 39 samples of post-mortem patients in this study. The majority were men (71.8%), with a mean age of 48.9 years old. Focal microvessel coronary thrombosis was found in 28%). The median D-Dimer level was increased from the average baseline (3460 mg/dl). However, there was no significant difference in D-dimer levels between focal microvessel coronary thrombosis incidents (p-value 0.827, C statistic AUC 0.523). The lack of focal necrosis in the surrounding tissue suggests that the thrombosis resulted from proximal embolization to distal capillary coronary, which already happened before, rather than the primary in-situ process in microvascular, hence may explain why D-Dimer was not correlated with the finding of coronary microvascular thrombosis in this study. Conclusion: D-dimer serum levels were not associated with focal microvessel thrombi in post-mortem COVID-19 patients. This result supports previous studies that showed D-Dimer was not specific to detect thrombosis in microvascular.

Item Type: Article
Subjects: R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions: 01. Fakultas Kedokteran > Ilmu Kardiologi Dan Kedokteran Vaskular (Spesialis)
Creators:
CreatorsNIM
Achmad Lefi, AchmadNIDN8827700016
Lalu Galih Pratama Rinjani, -UNSPECIFIED
Muhammad Yusuf Alsagaff, -UNSPECIFIED
Raden Mohammad Budiarto, -UNSPECIFIED
Priangga Adi Wiratama, -UNSPECIFIED
Etty Hary Kusumastuti, -UNSPECIFIED
Isnin Anang Marhana, -UNSPECIFIED
Alfian Nur Rosyid, -UNSPECIFIED
Dwi Wahyu, -UNSPECIFIED
Bambang Pujo Semedi, -UNSPECIFIED
Ricardo Adrian Nugraha, -UNSPECIFIED
Ryan Ernast Intan, -UNSPECIFIED
Muhammad Ramadhan, -UNSPECIFIED
Ika Caesarina, -UNSPECIFIED
Asiyah Nurul Fadila, -UNSPECIFIED
Muhammad Surya Tiyantara, -UNSPECIFIED
Gilang Muhammad Setyo Nugroho, -UNSPECIFIED
Ummi Maimunah, -UNSPECIFIED
Edi Suyanto, -UNSPECIFIED
Adhitri Anggoro, -UNSPECIFIED
I Komang Rusgi Yandi, -UNSPECIFIED
Jilieanastasia Godrace Lilihata, -UNSPECIFIED
Depositing User: arys fk
Date Deposited: 14 Sep 2023 03:22
Last Modified: 17 Oct 2023 08:18
URI: http://repository.unair.ac.id/id/eprint/128138
Sosial Share:

Actions (login required)

View Item View Item