Correlation of Surfactant Protein-D (SP-D) Serum Levels with ARDS Severity and Mortality in Covid-19 Patients in Indonesia

Alexander Agustama, - and Anna Surgean Veterini, Anna and Arie Utariani, - Correlation of Surfactant Protein-D (SP-D) Serum Levels with ARDS Severity and Mortality in Covid-19 Patients in Indonesia. Acta Medica Academica, 51 (1). pp. 21-28. ISSN 1840-2879

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Official URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC99828...

Abstract

Abstract Objective. The purpose of this research was to investigate the correlation between serum levels of surfactant protein-D (SP-D) with acute respiratory distress syndrome (ARDS) severity and mortality in COVID-19. Materials and Method. This was a prospective cohort research study that included 76 patients in the period from July to October 2020. SP-D serum levels were taken upon admission to the hospital, the diagnosis of ARDS and its grade were confirmed according to the WHO criteria, and then patients were observed for 28-day mortality. Results. The mean SP-D serum levels from 76 patients were 39.33 ng/ml (SD±31.884 ng/ml). The statistical analysis showed that there was a significant correlation between SP-D serum levels and the severity of ARDS upon admission to the hospital (P=0.04, Spearman’s rank correlation coefficient (rs)=0.26), but the correlation between serum levels of SP-D and mortality was not statistically significant (P=0.89; rs=-0.016). Conclusion. SP-D serum levels had a significant but weak correlation with ARDS severity, but were not significant for mortality.

Item Type: Article
Subjects: R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions: 01. Fakultas Kedokteran > Anestesiologi dan Reanimasi
Creators:
CreatorsNIM
Alexander Agustama, -UNSPECIFIED
Anna Surgean Veterini, AnnaNIDN8985700020
Arie Utariani, -UNSPECIFIED
Depositing User: arys fk
Date Deposited: 23 Oct 2023 00:08
Last Modified: 23 Oct 2023 00:08
URI: http://repository.unair.ac.id/id/eprint/128405
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