Surfactant Protein-D: The Potential ARDS Biomarker And Its Role In COVID-19 Repository

Surfactant Protein-D: The Potential ARDS Biomarker And Its Role In COVID-19

Alexander Agustama, - and Anna Surgean Veterini, Anna and Arie Utariani, - Surfactant Protein-D: The Potential ARDS Biomarker And Its Role In COVID-19. International Journal of Scientific Advances (IJSCIA), 3 (1). pp. 83-86. ISSN '2708-7972

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Official URL: https://www.ijscia.com/full-text-volume-3-issue-1-...

Abstract

Abstract As of September 2021, the number of patients diagnosed with COVID-19 worldwide has exceeded 221 million; while the Case Fatality Rate in 215 countries and regions is 2.06%. Acute Respiratory Distress Syndrome (ARDS) is the most common complication of COVID-19 and was reported had a 28-day mortality rate of 74%. Pulmonary injury in ARDS is caused by damage to the alveolar epithelium and pulmonary vascular endothelium caused by both direct virulence of SARS-CoV-2 and an inflammatory reaction that mediates neutrophil activation, leading to diffuse alveolar damage, pulmonary edema and surfactant dysfunction. Under inflammatory conditions, such as ARDS, increased alveolar-capillary permeability may result in alveolar Surfactant Protein-D (SP-D) leakage into the circulation, thus SP-D can be used as a specific biomarker of pulmonary epithelial damage and acute lung injury. SP-D is a specific biomarker of lung epithelial injury and has been shown to correlate with the severity and mortality of ARDS (COVID-19 and non COVID-19). Therefore, the use of SP-D as a prognostic biomarker in COVID-19 cases can be considered.

Item Type:

Article

Subjects:

R Medicine > R Medicine (General) > R5-920 Medicine (General)

Divisions:

01. Fakultas Kedokteran > Anestesiologi dan Reanimasi

Creators: