Arina D. Puspitasari, - and Daniel Dwi Christiananta Salean, - and Didik Hasmono, - and Rudy Hartono, - and Meity Ardiana, Meity (2021) A Study of anticoagulant therapy in patients with coronary artery disease. Journal of Basic and Clinical Physiology and Pharmacology, 32 (4). pp. 473-478.

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Abstract

Abstract Objectives One of the methods used to treat coronary artery disease (CAD) is anticoagulant therapy, which involves administering anticoagulants to patients that inhibit the arrangement and actuation of clotting factors. Anticoagulant therapy in patients with CAD must be monitored and evaluated because its greatest side effect is the risk of bleeding. The research aimed to analyze anticoagulants used in therapy for CAD patients and identify potential adverse drug reactions and adverse drug interactions. Methods This was an observational study which collected data retrospectively at Bhayangkara Hospital Surabaya. Patient data had to meet the requirements for inclusion, which were patients treated for a diagnosis of CAD with anticoagulant therapy and were in conditions with or without complications and comorbid diseases. Data were obtained from 40 patient medical records. The data were then processed descriptively. Results Most patients were male (80%) and aged 61–70 years old (37.5%). Fondaparinux was administered to 18 patients at a dose of 1 × 2.5 mg SC. Furthermore, enoxaparin was administered to 15 patients at a dose of 2 × 60 mg SC, and seven patients received warfarin at a dose of 1 × 2–4 mg per oral. Conclusions The anticoagulants used in this study were fondaparinux 1 × 2.5 mg SC (45%), enoxaparin 2 × 60 mg SC (37.5%), and warfarin 1 × 2–4 mg PO (17.5%). Side effects of the anticoagulants were absent. However, drug interactions with aspirin, clopidogrel, and allopurinol increased the risk of bleeding.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	01. Fakultas Kedokteran > Ilmu Kardiologi Dan Kedokteran Vaskular (Spesialis)
Creators:	Creators NIM Arina D. Puspitasari, - UNSPECIFIED Daniel Dwi Christiananta Salean, - UNSPECIFIED Didik Hasmono, - UNSPECIFIED Rudy Hartono, - UNSPECIFIED Meity Ardiana, Meity NIDN8925700020
Depositing User:	arys fk
Date Deposited:	23 Oct 2023 03:54
Last Modified:	18 Mar 2024 23:51
URI:	http://repository.unair.ac.id/id/eprint/128425
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