Ernawati, - and Aditiawarman, Aditiawarman and Salsabila Nabilah Rifdah, - and Agus Sulistyono, - (2023) Antihypertensive Choices during Pregnancy in Limited Setting. Pharmacognosy Journal, 15 (2). pp. 15-46. ISSN '0975-3575

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Abstract

Abstract Background: Antihypertensive agents used during pregnancy may vary from institution to institution and depend on resource availability. Objective: This study aimed to determine the profile of antihypertensive drugs used in pregnancy in low-middle-income countries and the impact of these drugs on maternal and fetal outcomes. Materials and Methods: This is a retrospective study on hypertensive pregnant patients admitted to the emergency unit at a tertiary referral Hospital in Indonesia. The type of hypertension during pregnancy, antihypertensive drugs, side effect, and maternal and perinatal outcomes was extracted from medical hospital records. Results: A total of 762 hypertensive pregnant women were recruited; 61 were diagnosed with preeclampsia, 491 were preeclampsia with severe features and 174 were chronic hypertension superimposed preeclampsia, and 81.54% of them received antihypertension therapy. The most commonly prescribed antihypertensive drugs were combination therapy of nifedipine and methyldopa (96.7%), followed by monotherapy of methyldopa (2.3%), nicardipine (1.1%), and nifedipine (0.2%). Most of the patients successfully attained a Systolic blood pressure<160mmHg. Tachycardia was reported in 47 (7.9%) pregnant women who received antihypertensive medication; none reported hypotension and arrhythmia. Conclusion: Nifedipine and methyldopa are choices for an antihypertensive agent in limited resources, either monotherapy or combined. Nifedipine's immediate release can be used with a low risk of hypotension.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General) > R5-920 Medicine (General)
Divisions:	01. Fakultas Kedokteran > Obstetri Dan Ginekologi (Sub Spesialis)
Creators:	Creators NIM Ernawati, - UNSPECIFIED Aditiawarman, Aditiawarman NIDN8837700016 Salsabila Nabilah Rifdah, - UNSPECIFIED Agus Sulistyono, - UNSPECIFIED
Depositing User:	arys fk
Date Deposited:	30 Oct 2023 00:13
Last Modified:	30 Oct 2023 00:13
URI:	http://repository.unair.ac.id/id/eprint/128552
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