Muhammad Thowawi Elziyad Purnama, - (2014) Potensi Mycotoxin Binder Terhadap Jumlah Folikel, Korpus Luteum, Ekspresi Caspase 9 Ovarium dan Morfologi Fetus Mencit (Mus Musculus) Bunting Yang Terpapar Zearalenon. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Zearalenone is a resorcylic acid lactone compound that is produced by fungal Fusarium graminearum infection of edible grains and is believed to influence reproduction by binding to estrogen receptors. This study examined the potential of mycotoxin binders to eliminate the effect of zeara1enone on the total follicles, corpus luteum, expression of caspase 9 ovaries as well as the amount of lenght and weight of fetus in pregnant mice (Mus musculus). We analyzed 20 pregnant mices specimens randomly divided into 5 groups. All groups were given treatment per oral with sonde till 10 days. K + as positive control weren't treated zeara1enone and mycotoxin binders, K- as negative control were treated with zeara1enone 0,1 mg/mice/day, PI were treated with zeara1enone 0,1 mg/mice/day and mycotoxin binders 0,5 mg/mice/day, P2 were treated with zeara1enone 0,1 mg/mice/day and mycotoxin binders I mg/mice/day, P3 were treated with zeara1enone 0,1 mg/mice/day and mycotoxin binders 2 mg/mice/day. The data was analyzed by ANOV A test. If there is a significant followed by Fisher's LSD test. The result showed that the amount of total follicles had a significant difference (p<0,05) between K- with P3. The result of corpus luteum showed not significant difference (p>0,05) between K+, K-, PI, and P2. The other result

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