Agus Maulana, - and Marjono Dwi Wibowo, Marjono (2022) Description Of Neutrophil-Lymphocyte Ratio In Patients With Thyroid Nodules Study Description At Dr Soetomo Hospital Period January 2018 – December 2020. International Journal of Research Publication, 100 (1). pp. 142-167. ISSN '2349 – 9788

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Abstract

Abstract Background:Thyroid nodules are found in more than 50% of patients using ultrasonography. The incidence of thyroid nodules in the population is increasing, between 5% and 15% are malignant nodules. In today's era, to identify the exact nature of thyroid nodules is very necessary, because thyroid cancer is the most common endocrine malignancy that occurs in thyroid nodules. The inflammatory process plays a major role in many cancer events, including tumor development, growth, clinical presentation, and prognosis. The neutrophil/lymphocyte ratio (NLR) is a simple index of the systemic inflammatory response. This study aims to describe the ratio of neutrophils and lymphocytes in thyroid nodules in patients at RSUD dr. Soetomo Surabaya. Method: In 102 cases of thyroid nodules, both benign and malignant, were retrospectively analyzed. We evaluated the neutrophil lymphocyte ratio with postoperative pathological anatomic outcomes. Complete blood count with differential count taken before surgery. The NLR was calculated by dividing the preoperative neutrophil count by the lymphocyte count. Samples were categorized into low grade (NLR < 1.91) and high grade (NLR 1.92). Results: There was a statistically significant difference in the neutrophil-lymphocyte ratio between benign thyroid nodules and malignant thyroid nodules (p=0.001). Low NLR values <1.91 were found in 25% of patients with benign thyroid nodules and 9.82% of patients with malignant thyroid nodules. High NLR values 1.92 were found in 25% of patients with benign thyroid nodules and 40.18% of patients with malignant thyroid nodules. Conclusion: Patients with malignant thyroid nodules tend to have high NLR, whereas patients with benign thyroid nodules tend to have lower NLR.

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