Wimpie L Pangkahila, - (1997) SUNTIKAN PROSTAGLANDIN E, SECARA INTRAKAVERNOSA MENGHAMBAT NOREPINEPHRINE SEHINGGA MENIMBULKAN EREKSI PADA PENDERITA IMPOTENSI PSIKOGENIK. Disertasi thesis, UNIVERSITAS AIRLANGGA.

Text 11 SUNTIKAN PROSTAGLANDIN E.pdf Download (6MB)

Abstract

This study was performed to understand the mechanism of intracavemous injection of prostaglandin E1 producing spontaneous erection and recover the erectile function in psychogenic impotence, especially in relation with the role of norepinephrine. The hypotheses of the study were (1) inttacavemous injection of prostaglandin E.inhtbits norepinephrine release in corpus cavemosmn thereby elicits spontaneous erection in psychogenic impotent patients, (2) erection obtained and the ability to have sexual intercourse produce decreased sexual auxicty, aad (3) dccreascd sexual amdety inlubits systemic norepinephrine release thereby produces recovery of the erectile function. The samples were 30 psychogenic impotent males aged of 25-49 years old selected by systematic nmdom sampling. Samples were then devided into two groups by nmdom permuted blocks into treatment group (20 samples) and control group (10 samples). This study is an experimental study using the design of pre-post test control group. Before treatment. samples answered the questionuaire for testing erectile abilitJ and for testing 1he aaxiety of sexual failure. Before treatment, the systemic blood was drawn from both groups for norepinephrine level examination. DuriDg treatment, the treatment group received intracavemous injection of prostaglandin E 1 in optimum dose once weekly, whereas the control group received intracavemous injection of Iml NaO once weekly.TotWJy 4 injections were given to each sample. In the fourth injection, ~ full erection achieved in the treatment group, the penile and systemic blood were drawn. In the control group,. the systemic blood was drawn at the same time with full erection. AJ. detumescence., the penile blood of 1he treatment group was drawn again, whereas in the control group the systemic blood was drawn at the same time with detumescence. After the study that was one month after the last injection, the systemic blood of both groups were drawn again for norepinephrine level examination. Finally samples answered the same questionnaire. The data were analysed statistically by nonnali1¥ test (Kolmogorov Smimov Goodness of Fit test), homogeneity test, Student’ s t test, and regression. The results showed that the hypotheses were received and the objectives were achieved.

Actions (login required)

View Item