Nasronudin (2005) Efek Pernyataan Diagnosis Terinfeksi HIV/AIDS Terhadap Mekanisme Apoptos Limfosit T-CD4 Pada Penderita HIV / AIDS. Disertasi thesis, Universitas Airlangga.

Text 11. EFEK PERNYATAAN DIAGNOSIS TERINFEKSI - NASRONUDIN.pdf Download (6MB)

Abstract

HIV/AIDS until now is still a global health problem including in Indonesia. The T-CD4 lymphocytes apoptosis mechanism in HIV/AIDS infection through the Heat shock protein 70 (Hsp70) mediated pathway is still unclear. The objective of this study was to disclose the effect of HIVIAIDS infection diagnosis to T-CD4 lymphocytes apoptosis mechanism in HIV/AIDS patients. Fourteen HIV/AIDS infected patients taken by simple random sampling were emolled in this research. Fourteen persons having a high risk of HIV infection, but still nonreactive, as revealed in HIV serology test, served as control. All subjects and controls were subjected to three-times examinations for ACTH, cortisol, Hsp70, anti Hsp70, T lymphocytes DNA fragmentation, and CD4 count. The first examination (day 0) was done two hours after the signing of informed consent while the patients still did not know about their HIV infection status. The second examination (day 7) was carried out when the patients were in acute stress condition after HIV/AIDS infection diagnosis was informed At the third examination (day 31), the patients were in chronic stress condition and showed acceptance of this disease. The results of this research were analysed by multivariate analysis. The first examination revealed that CD4 decreased both in HIV/AIDS infection and non-HIV/AIDS infection group of less than 1000 cells/mm3. The decrease progession in the HIV/AIDS group is faster than that in non HIV/AIDS infection. This study demonstrated that in HIV/AIDS infection group Hsp70 had a higher level than that in non HIV/AIDS infection.

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