Nia Kristiningrum, - (2004) Studi Perbandingan Kinetika Peruraian Sefaleksin dan N-4-Metilbenzoilsefaleksin Pada pH 8,00. Skripsi thesis, Universitas Airlangga.

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Abstract

This research was done to compare stability of cephalexin and its derivate, N-4-methylbenzoilcephalexin. N-4-methylbenzoilcephalexin has a great potency to be developed furthermore, because it is more active against P. aeruginosa than cephalexin. The stability was determined by studying degradation of these compounds by comparing their physical chemistry’s parameters, which are reaction rate (k), half-life period (t1/2), shelf life (t90) and energy of activation (Ea). It was done by studying degradation of medicines at various temperature (40, 60, 70, 80oC) and various time (30, 60, 90, 120, 150 minutes) in condition pH 8.00. A quantitative analysis was done by colorimetric method. It was obtained that N-4- mehtylbenzoilcephalexin more stable than cephalexin.

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