MUHAMMAD BRAHMA DWIANANDRA (2022) THE CORRELATION OF LOW DOSE AND LONG TERM CORTICOSTEROID THERAPY ON OSTEOPOROSIS IN PATIENT WITH CHRONIC DISEASE: A SYSTEMATIC REVIEW. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background: Corticosteroids are frequently used as immunosuppressants and strong anti-inflammatories; some patients must take the medicine for more than three months. In the general population, 2% of women under the age of 50 take corticosteroids, particularly in the case of patients with chronic diseases who do so as a form of treatment. A total of 19.6% to 38% of the population who took corticosteroids went on to develop glucocorticoid-induced osteoporosis. Method: The method is looking for articles which consist of many study design which include the data upon patient with chronic disease who consume corticosteroid more than 3 months and most of the study population consume low dose. The patient bone mineral density assessment is using DXA scan, no diabetic patient included, patient consume supplementation or treatment for osteoporosis, and paediatric patient also excluded. For the article from databases we exclude review article, experimental study, and we only include English language article only. Result: results of bone mineral density from DXA scan shows that femoral neck t score show -0,30 and other two Z score show -0,29 and -0,83. From the result of vertebrae BMD shows that T-score of -0,3 and Z score of -0,75 and 0,07. A single article show the BMD of forearm is -1,2 and lastly T-score show 0,41 on whole body BMD. Conclusion: From 7 article obtained from searching and filtering of article. The article found to observe the effect of low dose and long-term corticosteroid to bone mineral density in patient with chronic disease is not significant, which also being influenced by multi factorial such as the onset of disease, part of the bone that assessed, and others

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