Mohamad Kharis Suhud, - (2022) Efek Neuroprotektif Madu Hutan Apis Dorsata Terhadap Jumlah Neuron Pada Cerebrum Dan Cerebellum Mus Musculus Yang Diinduksi Monosodium Glutamat. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

"This study aims to determine the preventive effect of Apis dorsata forest honey on the number of pyramidal cerebrum neurons and purkinje cerebellum neurons of mice (Mus musculus) exposed to monosodium glutamate (MSG). This study used 25 mice which were divided into 5 groups. In the K- group, only aquadest was given. The K+ group was given 4mg/gBB of MSG. Groups P1, P2, and P3 were given Apis dorsata forest honey at a dose of 53.82mg/20gBW, 107.64mg/20gBW, and 161.46mg/20gBW. All treatments were carried out orally for 52 days. The results showed that the average number of cerebral pyramidal neurons in the K-, K+, P1, P2, and P3 groups was 12.24±0.607; 7.24±2.875; 12.48±1.513; 15.72±0.944; and 19.28±2.827. The mean number of purkinje cerebellar neurons was 4.8±1,456; 2.08±0.807; 3.08±1.035; 3.56±0.434; and 4.68±1,390. The average number of pyramidal cerebrum neurons and purkinje cerebellum neurons in the group given Apis dorsata forest honey was higher than the group that was only exposed to MSG without Apis dorsata forest honey. The results of statistical analysis showed that there was a significant difference between the group that was given Apis dorsata forest honey and exposed to MSG compared to the group that was only exposed to MSG without being given Apis dorsata forest honey. It can be concluded that the administration of Apis dorsata forest honey can maintain the number of pyramidal cerebrum neurons and purkinje cerebellar neurons in mice exposed to MSG. "

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