Nuryanti, Archadian and Ruslin and Shafira, Hana and Mumtazrahmah, Nadhira Afifah and Hanifah, Nadia Nur and Sarasati, Andari (2026) Aloe Vera, Trigona Honey, and Chitosan-Based Antibacterial Nanospray Modulates Mast Cells and Angiogenesis in Gingival Wound Healing. Tropical Journal of Natural Product Research, 10 (4). 8543 - 8549.

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Abstract

Gingival wound healing is a complex biological process involving inflammatory, proliferative, and remodelling phases, all of which influence the rate and quality of tissue repair. This study aimed to evaluate the effects of a nanospray formulation containing Aloe vera extract, Trigona honey, and chitosan on bacterial inhibition, angiogenesis, and mast cell activity during gingival wound healing. An in vitro antibacterial assay against Porphyromonas gingivalis was performed according to standard procedure, followed by in vivo histological evaluation using 45 male Wistar rats divided into three groups: chitosan spray as a negative control, the nanospray formulation as the treatment group, and Aloclair® as a positive control. Gingival tissue samples were collected and analyzed on days 1, 3, 5, 7, and 14 post-treatment. The nanospray demonstrated significant antibacterial activity against P. gingivalis and significantly enhanced gingival wound healing by promoting angiogenesis and reducing mast cell counts compared to the control groups (p < 0.05). These findings indicate that the nanospray formulation effectively supports bacterial inhibition and accelerates tissue repair, suggesting its potential as a therapeutic approach for gingival wound management. © 2026 Nuryanti et al.

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