Farizah Izazi, - (2018) Profil Toksisitas Oral Sub Kronis 90 Hari Ekstrak Etanol 70% Kulit Buah Citrus Nobilis Lour. Pada Tikus. Thesis thesis, UNIVERSITAS AIRLANGGA.

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Abstract

This research used 40 male 40 female white Galur Wistar rats in sub-chronic toxicity and each divided into 4 groups (control group giving CMC Na 0,5%, dose group 40 mg/kg BB, dose group 200 mg/kg BB, and dose group 1000 mg/kb BB). Each group consists of 10 males and 10 females. Each cage contains 5 rats of the same age and gender, fed and drunk in ad libitum method. Furthermore, the rats are being weighing in. 70% extraction of Citrus nobilis Lour peel is orally given to the rats, every day for 90 days accordance with the group. On the 90th days, the rat is not fed for 14 hours then drugged with ether to take their blood sample. The blood sample is then analyzed at labkesda (Local Lab of State), Surabaya Indonesia to get of hematology and biochemistry assessment result and than histophatolgy at Veterinary Faculty, Airlangga University, Surabaya, Indonesia. Data will be processed by multivariate analysis PCA (Principle Component Analysis). PCA showed the formation of sample groups which means that different origin area and showed the identity of artificial sample and test samples.

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