Vijayakumaran, Mishalini and Velu, Monisha Thanka and Abidin, Azrina Zainal and Bahari, Hasnah and Othman, Fezah and Wen, Goh Khang and Rahmadi, Mahardian and Balan, Santhra Segaran (2026) Anti-Psoriatic activity of Coffee liberica pulp extract on Imiquimod-induced Psoriasis-like dermatitis in Balb/C mice. Open Veterinary Journal, 16 (3). 1725 - 1733.
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Abstract
Background: Psoriasis, also known as Psoriasis (Pso), is a persistent skin disorder characterized by erythematous, indurated, scaly, itchy, and often painful plaques. Although conventional medicine has been employed to treat psoriasis, it may cause adverse effects owing to its long-term use. Consequently, alternative medicine has become a popular option to address this issue. Coffee liberica pulp, a commonly overlooked waste product, has been found to have numerous benefits for humans. Aim: This study investigated the effectiveness of Liberia coffee pulp extract using an imiquimod (IMQ)-induced mouse model that replicated several features of psoriasis in humans. Methods: The study involved applying IMQ cream and other topical treatments to the shaved dorsal skin of mice. The psoriasis Area and Severity Index score, body weight, organ weight, expression of interleukins in the skin and serum, and full blood count were measured. Results: The results showed significant changes (p < 0.05) in skin weights in the negative control group compared with other groups. No significant changes in other organ weight were observed in any groups. However, the full blood count revealed significant changes (p < 0.05) in haemoglobin and white blood cell counts. The levels of interleukin 17a, interleukin 22, and interleukin 23 levels showed significant differences (p < 0.05) between the positive and treatment groups. Conclusion: This study found that C. liberica pulp has anti-inflammatory and antioxidant properties that help reduce skin inflammation. These findings suggest that C. liberica is a cost-effective source of natural antioxidants that can be used to alleviate psoriasis. © 2026, Faculty of Veterinary Medicine, University of Tripoli. All rights reserved.
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| Additional Information: | Cited by: 0; All Open Access; Gold Open Access | ||||||||||||||||||
| Uncontrolled Keywords: | antioxidant; antipsoriasis agent; clobetasol propionate; coffee liberica pulp extract; corticosteroid; hemoglobin; imiquimod; interleukin 17; interleukin 22; interleukin 23; interleukin derivative; plant extract; unclassified drug; acclimatization; alternative medicine; anemia; anemia of chronic disease; animal experiment; animal model; animal tissue; antiinflammatory activity; antioxidant activity; Article; blood cell count; blood sampling; body weight; controlled study; data analysis; dermatitis; enzyme linked immunosorbent assay; erythema; hematocrit; homeostasis; inflammation; leukocyte count; leukocytosis; mouse; neutrophil; neutrophilia; nonhuman; organ weight; platelet count; psoriasis; psoriasis area and severity index score; scoring system; skin disease; splenomegaly; statistical analysis | ||||||||||||||||||
| Subjects: | R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica |
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| Depositing User: | mat sjafi'i | ||||||||||||||||||
| Date Deposited: | 15 Sep 2026 03:32 | ||||||||||||||||||
| Last Modified: | 15 Sep 2026 03:32 | ||||||||||||||||||
| URI: | http://repository.unair.ac.id/id/eprint/145768 | ||||||||||||||||||
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