Sutanto, Henry and Ashariati, Ami and Savitri, Merlyna and Hendarsih, Een (2026) Beyond Physical Toxicities: Identifying Psychosocial Domains Requiring Integrated Support in Breast Cancer Pharmacotherapy. Psycho-Oncology, 35 (1). ISSN 10579249

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Abstract

Background: Cancer pharmacotherapy imposes substantial physical and psychosocial burdens that affect patients' quality of life (QoL). While oncologic outcomes are well studied, the psychological dimensions particularly future perspective, emotional resilience, and body image remain under integrated into routine care. The growing recognition of psycho-oncology highlights the need for synergistic collaboration between oncology and clinical psychology. Aim: To evaluate changes in QoL before and after pharmacotherapy among women with breast cancer and identify domains most vulnerable to psychological distress, thereby informing the need for integrated psycho-oncologic care. Methods: This prospective study included 106 women with breast cancer undergoing pharmacotherapy. Sociodemographic and clinical characteristics were collected, including cancer stage, treatment modalities, and baseline cardiometabolic parameters. QoL was assessed pre- and post-treatment using EORTC QLQ-C30 and BR23 instruments. Paired comparisons were performed using Wilcoxon signed-rank tests, and correlations with age were analyzed using Spearman or Pearson methods as appropriate. Results: Global health status declined significantly after pharmacotherapy (83.3 to 66.7; p = 0.002). Functional domainsâ including physical, role, and social functioningâ also worsened, while emotional functioning improved modestly. Symptom burden increased across fatigue, nausea, pain, appetite loss, and systemic side effects (all p < 0.001). Breast-cancerâ specific domains such as body image and future perspective showed minimal change but remained highly variable, indicating psychosocial vulnerability. Distress related to hair loss demonstrated a modest inverse correlation with age (r = â0.296; p = 0.003). Conclusion: Pharmacotherapy substantially reduces multiple QoL domains, highlighting symptomâ function trade-offs and persistent psychological concerns. The patterns in emotional functioning and future perspective indicate unmet psychosocial needs. These findings underscore the imperative for integrated psycho-oncology models to enhance holistic survivorship care. © 2026 John Wiley & Sons Ltd.

Item Type:	Article
Additional Information:	Cited by: 2; All Open Access; Bronze Open Access
Uncontrolled Keywords:	Adult; Aged; Antineoplastic Agents; Body Image; Breast Neoplasms; Fatigue; Female; Humans; Middle Aged; Prospective Studies; Psychological Distress; Quality of Life; bevacizumab; carboplatin; cyclophosphamide; docetaxel; doxorubicin; epirubicin; eribulin; fulvestrant; gemcitabine; goserelin; letrozole; leuprorelin; methotrexate; paclitaxel; tamoxifen; trastuzumab; vinorelbine tartrate; antineoplastic agent; adult; Article; body image; breast cancer; breast tumor; cancer staging; cohort analysis; constipation; correlation analysis; distress syndrome; drug therapy; dyspnea; emotional stress; European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30; fatigue; female; hair loss; health status; human; insomnia; loss of appetite; major clinical study; mental stress; middle aged; nausea; observational study; pain; patient-reported outcome; prospective study; psycho-oncology; psychological functioning; psychological resilience; quality of life; quality of life assessment; sexuality; social interaction; social psychology; social vulnerability; sociodemographics; survivorship; symptom burden; toxicity; aged; breast tumor; distress syndrome; drug therapy; psychology; quality of life
Subjects:	R Medicine
Divisions:	Artikel Ilmiah > SCOPUS INDEXED JOURNAL
Creators:	Creators NIM Sutanto, Henry UNSPECIFIED Ashariati, Ami UNSPECIFIED Savitri, Merlyna UNSPECIFIED Hendarsih, Een UNSPECIFIED
Depositing User:	Nurma Harumiaty
Date Deposited:	02 Oct 2026 04:00
Last Modified:	02 Oct 2026 04:00
URI:	http://repository.unair.ac.id/id/eprint/145938
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