Christianto, David and Mertaniasih, Ni Made and Permatasari, Ariani and Purwono, Priyo Budi and Endraswari, Pepy Dwi and Atika (2025) Clinical, Radiological, and Molecular Profiles of Rifampicin-resistant Pulmonary Tuberculosis: A Cross-sectional Study from a Tertiary Referral Center in Indonesia. Journal of Pure and Applied Microbiology, 19 (4). 3095 - 3105. ISSN 09737510

Text (Article) JPAM_Vol_19_Issue4_p_3095-3105.pdf Download (361kB)

Abstract

Rifampicin-resistant tuberculosis (RR-TB) remains a major public health concern, and is characterized by diagnostic challenges and suboptimal treatment success. To better understand the factors influencing disease burden and outcomes, the present study investigated the clinical, demographic, radiological, and molecular characteristics of patients in a high-burden tertiary hospital in Indonesia. A cross-sectional study involving adult patients diagnosed with RR-TB at Dr. Soetomo General Hospital (Surabaya, Indonesia) was conducted to analyze clinical symptoms, comorbidities, radiographic findings, treatment regimens, and laboratory data, including sputum smear grades and IS6110â IS1081 cycle threshold (CT) values. Among 55 patients with RR-TB (mean age 45.1 years; 60 male), IS6110â IS1081 CT values exhibited significant inverse associations with the Modified Bandim TB Score (p=0.002) and chest pain (p=0.003), indicating higher bacterial burden in more symptomatic patients. CT values were also negatively correlated with sputum smear scores (r=-0.342; p=0.011). Treatment failure was independently associated with anemia (odds ratio OR 13.2, p=0.023) and a long-course regimen (OR 7.3, p=0.026). A higher bacterial burden, as reflected by lower IS6110â IS1081 CT values, was associated with greater disease severity and chest pain. Anemia and long-course regimens independently predicted treatment failure, highlighting the need for the early detection of patients at high risk and optimized treatment strategies for RR-TB management. © The Author(s) 2025. Open Access.

Actions (login required)

View Item