Hardlin, Diastry Fauziyah and Isadiartuti, Dewi and Hariyadi, Dewi Melani (2026) Konjac glucomannan: Properties, modifications and applications in pharmacy. Tropical Journal of Pharmaceutical Research, 25 (1). 103 - 113.

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Abstract

Konjac glucomannan (KGM) is a natural polysaccharide extracted from the tuber of Amorphophallus konjac, known for its biocompatibility, biodegradability, and safety, making it suitable for use in both the food and pharmaceutical industries. Nevertheless, its high viscosity and limited solubility present major obstacles for its use in pharmaceutical formulations. To overcome these challenges, various chemical and physical modification techniques such as hydrolysis, oxidation, and carboxymethylation have been employed to adjust their molecular weight, viscosity, and solubility characteristics to align with pharmaceutical formulation requirements. These modifications enable KGM to function as a drug delivery vehicle capable of controlled and targeted release, with potential applications in intracellular therapies, colon-targeted delivery systems, and oral nanocarriers for insulin and other bioactive agents. Its effectiveness as an excipient and drug carrier matrix is further supported by its ability to interact selectively with target cells, including macrophages, via mannose receptors and its inherent antioxidant and antidiabetic activities. The combination of its modifiability, pharmaceutical functionality, and therapeutic potential positions KGM as a strong candidate among natural polymers for the development of advanced biomaterial-based drug delivery systems. © 2026 The authors.

Item Type:	Article
Additional Information:	Cited by: 0; All Open Access; Gold Open Access
Uncontrolled Keywords:	antioxidant; biomaterial; drug carrier; etoricoxib; glucagon like peptide 1; insulin; konjac glucomannan; mannan; mannose receptor; polysaccharide; tumor necrosis factor; unclassified drug; Amorphophallus konjac; antidiabetic activity; Article; biocompatibility; biodegradability; biological activity; chemical analysis; controlled study; deacetylation; diabetes mellitus; drug delivery system; drug formulation; drug industry; glucose blood level; hydrolysis; hydrolysis kinetics; inflammation; Lactobacillus; lipid metabolism; macrophage; molecular weight; Mycobacterium abscessus infection; oxidation; pH measurement; pharmacy (shop); physical activity; protein methylation; solubility; sulfation; target cell; viscosity
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Artikel Ilmiah > SCOPUS INDEXED JOURNAL
Creators:	Creators NIM Hardlin, Diastry Fauziyah UNSPECIFIED Isadiartuti, Dewi UNSPECIFIED Hariyadi, Dewi Melani UNSPECIFIED
Depositing User:	Nurma Harumiaty
Date Deposited:	28 Sep 2026 01:50
Last Modified:	28 Sep 2026 01:52
URI:	http://repository.unair.ac.id/id/eprint/145979
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