Zelmira Amanda (2018) AKTIVITAS PROFILAKSIS ANTIMALARIA EKSTRAK ETANOL AKAR Helianthus annuus L. SECARA IN VIVO PADA MENCIT BALB/C. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Malaria is a disease transmitted through the bite of Anopheles mosquito which are infected by Plasmodium sp. Discovery of new medicinal plants is needed to provide alternative for prophylactic malaria drugs due to resistance, one of the plants is Helianthus annuus L. or commonly known as Sunflower plant.The objective of this study was to determine the effect of ethanolic extract of Helianthus annuus L. roots as prophylactic agent for malaria against mice. Helianthus annuus L. roots were macerated using 96% ethanol and tested in vivo in mice weighing 20- 35 grams. Mice were given ethanolic extract of Helianthus annuus L. with dose 100; 200; 400; 800 mg / kg body weight for -72, -48, -24, and -0 hours before being infected with Plasmodiun berghei through intraperitonial Blood smears sampling from each mice was performed 1 day after mice being infected to 7th day after mice being infected to determine the level of parasitemia and compared the result with untreated subjects. The results shown that ethanolic extract of Helianthus annuus L. roots had very good prophylactic activity against Plasmodium berghei 72 hours after mice being infected with its biggest inhibition activity shown by dose 400 mg/kg body weight with inhibition percentage of 79,15%. Different results shown when the prophylactic activity being observed until 6 days after mice being infected where every group inhibition activity weakens where its biggest inhibition activity shown by dose 100 mg/kg body weight with inhibition activity of 36,59%.

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