HAFIZHA AULIA AZMI, - (2020) UJl EFEKTIFITAS PELET ALENDRONAT DENGAN PEMBAWA BOVINE HYDROXYAPATITE-GELATIN DAN GLUTARALDEHID PADA MODEL DENGAN DEFEK TULANG AKIBAT OSTEOPOROSIS. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

ABSTRACT Osteoporosis is a bone metabolic disease which shown by low mass bone density. It most likely will cause bone fracture. Alendronate is a biphosphonate drug group which had potential to increase mineral bone density and lower the chance for fracture to happen in post-menopause woman osteoporosis. Oral alendronate caused side effect stomach irritation. jaw osteonecrosis, and had low bioavaibility. This study will fonnulate alendronate in implant pellet which effect locall y. This form will contain carrier bovine hydroxyapatite-ge latin where it's able to deliver alendronate and fill bone defect due to osteoporosis. The purpose of this study is to determine the effectiveness of pellet containing BHA-gelatin-alendronat if crosslinked by glutaraldehyde. The parameter used in this study is ALP concentration in blood where ALP is the marker of bone growth and bone rad iology using x-rays on the femur bone of mice. The result of this study on ALP concentration showed non-significant difference in between groups. In the group of 81-IA-GEL-ALE. the means level were 352,50±7,500. meanwhile with glutaraldehyde were 343,33± 120,478. This is showed by P-value number (0,27 1) bigger than the value of a (0,05). From the result of bone radiology, there was a closure 8,95% in 8 1 lAGEL- ALE group, meanwhile in glutara ldehyde group was 2,73%. It because glutaraldehyde strongly binds to gelatin while alendronate strongly binds with BHA. Alendronate is not completely detached from the carrier. Based on the result obtained, it showed that alendronate pellet which crosslinked with glutaraldehyde resulted in insignificant change in ALP in the blood on 6'" week of treatment and able to show a reduction of diameter on bone defect due to osteoporosis.

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