YORA WARDATI, 021011013 (2013) UJI BIOKOMPATIBILITAS EKSTRAK PROPOLIS DAN H2O2 3% TERHADAP SEL FIBROBLAS BABY HAMSTER KIDNEY-21 (BHK-21) (Uji Eksperimental Laboratoris). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background: Cytotoxicity evaluation is an early stage to assess the biocompatibility of a material or extract. Terms of root canal irrigation materials either one of them is a low cytotoxicity against periapical tissues. Hydrogen peroxide (H2O2) 3% is one of the irrigation materials commonly used but H2O2 is a free radicals. Propolis is a resinous material producted by honey bees and has been used as an herbal medicine for a long time. Propolis shown to have antioxidant properties, antiinflammatory, antimicrobial, and many other properties, and in previous studies suggest that propolis may eliminate the bacteria in root canal effectively therefore can be used as root canal irrigation. Purpose: This study aimed to compare the biocompatibility of 30% propolis extract and 3% H2O2 as a root canal irrigation. Method: BHK-21 cell line were divided into 2 groups of treatment, namely the group treated with the 30% propolis extract, and the group treated with 3% H2O2 for 2.5 minutes each group, and measured using the MTT assay. Data were analyzed with one-way ANNOVA with a significance level of 5% and Turkey HSD. Result: 30% propolis extract group had a greater optical density than the group 3% H2O2 . Conclusion: 30% propolis extract more biocompatible than (H2O2) 3% as root canal irrigation.

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