NOT ARICIA SARTIKA FITRAH S.P.N, 021011095 (2013) EFEK EKSTRAK PROPOLIS TERHADAP JUMLAH OSTEOBLAS TULANG ALVEOLAR CAVIA COBAYA PADA PERGERAKAN GIGI ORTODONTI (Studi Eksperimental Laboratoris). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background: Research has confirmed that natural substance, such as Propolis, contains flavanoid which is widely known its appearance increasing a number of osteoblast. Which can support and enhance the alveolar bone remodeling process. Purpose: This study was conducted to investigate the influence of administration Propolis extracts on osteoblast expression around alveolar bone during experimental tooth movement in Cavia cobaya. Material and methods: Cavia cobaya with an average weight 200-300grams were selected and randomly divided into two groups-only orthodontic tooth movement (K) and orthodontic tooth movement plus propolis (PGO-1) groups. PGO-1 received 3mg propolis extracts disolved to 2ml of aquades daily dose. After the 14 day separators were applied, the K and PGO-1, were eutanatized and their pre-maxillae were dissected and fixed. Histological examination was performed to determine the number of osteoblasts. A number of osteoblasts were counted under a light microscope with 1000 magnifications. Data was analyzed by Kolmogorov-Smirnov test and Independent-t-test. Results: Statistical analysis showed that number of osteoblasts were greater in the PGO-1 group than in the K group. The results of Kolmogorov- Smirnov test showed both groups have normal distribution, control groups and experimental groups respectively, 0,70 and 0,86 (p>0,05) and Indepent-t-test showed both groups has significant difference. Conclusion : The result suggests that administration of Propolis extract lead to increase in the number of osteoblast around alveolar bone in Cavia Cobaya during tooth movement

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