MARIA LAURENTIA SANJAYA, 020710165 (2010) EFEKTIFITAS EKSTRAK CINCAU HIJAU (Cyclea barbata Miers) TERHADAP PENYEMBUHAN LUKA KRONIS. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background: Cyclea barbata Miers is one of many Indonesian traditional plants which had been explored recently. Cyclea barbata Miers has many bioactive components such as flavonoid, polifenol and chlorophyl which all function as antioxidant. Antioxidant can be use against free-radicals. In chronic injury, free radicals which are produced excessively by inflammation process can prolong wound healing. Purpose: The aim of this study was to prove the effectiveness of Cyclea barbata Miers’s extract to heal chronic wounds of wistar mice. Method: This experiment uses post test only control group design. Twenty four mice are used and are divided into four groups: control group (KK) and three others treatment group. The first treatment group (KP-1) was treated with Cyclea barbata Miers for one day, the second group (KP-2) was treated for two days, and the third group (KP-3) was treated for three days. Pathological examination is used to count chronic inflammation cell, fibroblast, and capillary blood vessel. Data is presented as a table. One way anova test and post hoc test (LSD) are used in this experiment by SPSS 13 Windows. Result: The mean amount of chronic inflammation cell are KK=84,00; KP-1=64,33; KP-2=55,50; KP-3=45,83. Mean amount of fibroblas are KK=73,50; KP-1=101,83; KP-2=106,00; KP-3=125,83. Mean amount of blood vessel are KK=62,17; K-P1=93,67; KP-2=104,33; KP-3=109,33. In every group, significant differences are present when tested using One Way Anova test p=0,0. In LSD test, there are significant differences between KK with every groups and between KP-1 with KP-3. In Manova test, there are significant differences in chronic wound healing time. Conclusion: Applying Cyclea barbata Miers on chronic wound will affect its healing. It is found that the treatment with Cyclea barbata Miers for three days had the most effect on the healing process.

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