NOVENDY YOYADA, 020710037 (2011) PEMANFAATAN EKSTRAK DAUN SEREH ( Cymbopogon citratus ) TERHADAP KECEPATAN PENYEMBUHAN LUKA SAYAT. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background : Lemongrass (Cymbopogon citratus) is one of many Indonesia traditional plants which had been explored recently. Cympogon citratus has many bioactive components such as flavonoid and citral which all function as antioxidant. Antioxidant can be use against free-radicals. In chronic injury, free-radicals which are produced excessively by inflammation process can prolong wound healing. Purpose : the aim of this study is wants to know the advantage of cymbopogon citratus’s extract to accelerate healing of cuts in mice. Method : this experiment uses post test only control group design. Twenty four mices are used and divided into four groups : control group (KK) and three others treatment group. The first treatment group (KP-1) were treated with cymbopogon citratus 0.3 g/kg, the second group (KP-2) were treated with cymbopogon citratus 1 g/kg, the third group (KP-3) with cymbopogon citratus 2 g/kg. pathological examination is used to count chronic inflammation cell (macrophage, plasma cell, lymphocyte) , fibroblast, and capillary blood vessel. Data is presented as a table. One way anova test and post hoc test (LSD) are used in this experiment by SPSS 13 Windows. Result : our study indicated lemongrass has great potential in anti inflammatory. It shown at the treatment group, there was a decrease chronic inflammation cell (macrophage, plasma cell, lymphocyte) (KK X 88.67 ± 14.651 compare with KP-3 X45.83 ± 3.060),increased fibroblast (KK X 81.67 ± 6.439 compare with KP-3 X 113.67 ± 9.667), increased capillary blood vessel (KK X 73.67 ± 5.955 compare with KP-3 X 117.83 ± 9.32). in every group, significant differences are present when tested using One Way Anova test p=0,0. in LSD test, there are significant differences between KK with every groups and between KP -1 with KP-3. Conclusion : applying Cymbopogon Citratus on wound will affect its healing. It is found that the treatment with cymbopogon citratus 2g/kg had the most accelerate on the healing process.

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