KARIN NADIA FIRSTY, 021011150 (2014) EFEK KOMBINASI EKSTRAK TEMULAWAK (Curcuma Xanthorrhiza Roxb) DAN KETOCONAZOLE TERHADAP KOLONISASI CANDIDA ALBICANS. Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background: C. albicans is one of the manifestations of infection are most commonly found in immunocompromised patients. Candidiasis caused by C. albicans can be overcome by various types of anti-fungal. Recently, there are many cases of C. albicans’s resistance to the antifungal. Curcuma xanthorrhiza Roxb., was investigated for its antifungal activity using C. albicans. This study is to find out the effectiveness of combination of ketoconazole and Curcuma xanthorrhiza extract for oral candidiasis therapy. Objective: To study the combined effect of Curcuma xanthorrhiza with ketoconazole in inhibiting colonization of C. albicans. Methods: This research conducted in vitro by serial dilution method and colony’s calculation. This study used a sample of non ARV C. albicans stock derived from immunocompromised patients from Institute Tropical Disease, Airlangga University. This sample was recultured and then divided into 3 groups and given different treatments. Group 1 was given a single ketoconazole, group 2 was given C. xanthorrhiza extract, and group 3 was given a combination of both. In each group is performed serial dilution. In this serial dilution process, ketoconazole diluted with initial concentration of 4-0.0625 mg/mL, whereas is given constant in each tube=50%. After that, the colony were cross-checked and re-planted on SDA media. Serial dilution also conducted for Curcuma by diluted 10-0,15625 mg/L concentration. Then both were combined and divided into 3 concentration. Results: C. albicans was susceptible to combination of Curcuma 1,25 mg/mL and ketoconazole 0,5 mg/mL. Conclusion: It can be concluded that administration of ketoconazole combination of Curcuma xanthorrhiza extract-ketoconazole is more effective than single ketoconazole.

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