Anastasia Audrey (2015) Peningkatan Jumlah Fibroblas Pada Proses Penyembuhan Luka Sayatan Tikus Wistar (Rattus Norvegicus) Setelah Pemberian Ekstrak Kayu Manis (Cinnamomum Burmanii) (Penelitian Eksperimental Laboratoris). Skripsi thesis, UNIVERSITAS AIRLANGGA.

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Abstract

Background. Wound is a disruption of tissue integrity. Wound in the oral cavity can lead discomfort. Therefore proper wound healing process is needed. Cinnamon contains flavonoids, tanins, and saponins is expected to accelerate wound healing process as it increases the number of fibroblass. Objective. The aim of this study is to prove an increase in the number of fibroblass in the wound healing process of surgical incision on rat (Rattus norvegicus) after the application of cinnamon (cinnamomum burmanii) extract. Methods. 32 rats were divided into 2 groups, control group and the treatment group. 5 mm incision was conducted on the anterior vestibule of the mandible. Gel formulation containing 20% of cinnamon extract and CMC Na 3,0% was applied topically on the treatment group. On the 5th and the 7th day, the rats were sacrified and preceeded to histopathological preparations. After the fibroblas countings were completed, the results were analyzed statistically using One Way Anova. Result. There is significant difference between the control group and the treatment group with the significant value 0,000 (sig<0,05). Conclusion. There is an increase in the number of fibroblass in healing process of surgical incision on rat (Rattus norvegicus) after the application of cinnamon (Cinnamomum burmanii) extract.

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